Clonal growth of human ovarian cancer cell lines is enhanced by granulocyte-macrophage colony-stimulating factor (GM-CSF) : G. Cimoli, P. Russo, G. Billi, G.L. Mariani, R. Rosso, A. Ardizzoni and M. Venturini. IST - Genova, Italy...
Subclonal evolution of four breast cancers over 2–15 years. a–d Subclonal evolution of breast cancer patients #1 to #4 through treatment. Left side shows variant allele frequencies of copy-neutral somatic SNVs and indels (WGS) organized into clusters, with relevant cancer-associated mutations ...
Punctuated copy number evolution and clonal stasis in triple-negative breast cancer. Nat. Genet. 48, 1119–1130 (2016). CAS PubMed PubMed Central Google Scholar Notta, F. et al. A renewed model of pancreatic cancer evolution based on genomic rearrangement patterns. Nature 538, 378–382 (...
Clonal evolution of a tumor ecosystem depends on different selection pressures that are principally immune and treatment mediated. We integrate RNA-seq, DNA sequencing, TCR-seq and SNP array data across multiple regions of liver cancer specimens to map spatio-temporal interactions between cancer and ...
et al. Divergent modes of clonal spread and intraperitoneal mixing in high-grade serous ovarian cancer. Nat. Genet. 48, 758–767 (2016). Article CAS PubMed Google Scholar de Bruin, E. C. et al. Spatial and temporal diversity in genomic instability processes defines lung cancer evolution. ...
Finally, we outline approaches to address cancer systemically, taking into account ITH and tumor evolution. Intra-tumor Heterogeneity: Patterns and Prevalence How Much Heterogeneity Is There? Genomic diversity within single tumors has long been recognized. Indeed, as early as 1958, evolutionary ...
Clonal selection of cancer evolution We applied an evolutionary genomics approach (dN/dS ratio) to evaluate the clonal selection patterns of tumors with distinct immunogram subtypes. The dN/dS ratio, the ratio of nonsynonymous mutations to synonymous mutations, is a method for identifying the selecti...
DeconstructSigs: delineating mutational processes in single tumors distinguishes DNA repair deficiencies and patterns of carcinoma evolution. Genome Biol. 17, 31 (2016). Article CAS PubMed PubMed Central Google Scholar Alexandrov, L.B. et al. Signatures of mutational processes in human cancer. ...
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et al. Universal patterns of selection in cancer and somatic tissues. Cell 171, 1029–1041.e21 (2017). Article CAS PubMed PubMed Central Google Scholar Khan, K. H. et al. Longitudinal liquid biopsy and mathematical modeling of clonal evolution forecast time to treatment failure in the ...