[143,144]. It controls numerous life processes by linking extra and intracellular cues from nutrients, stress, growth factors, and hormones and is associated with an increasing number of pathological conditions including dysfunction, cancer, obesity, type 2 diabetes, andneurodegeneration[145]. In ...
reflecting the ease with which cancer cells located on the ovaries can subsequently seed additional peritoneal sites. Although the precise timing of this progression depends on assumptions related to mutation rates, which may change during tumor progression, models employing different rates...
Ovarian cancer (OC) has the highest mortality rate and the poorest prognosis among gynecological malignancies8. As in most other cancers, TGF-β and miRNA play important roles in the occurrence, progression, and recurrence of OC. A majority of these cancers are derived from the ovarian surface ...
A positive family history of breast or ovarian cancer is a well-recognized risk factor in the breast cancer history; it is present in nearly 5–10% of patients. A family history of breast, ovarian, pancreatic cancer, metastatic or high grade prostate cancer or other unusual cancer in first-...
Ovarian cancer is the most lethal gynecological cancer. As the primary treatment, chemotherapy has a response rate of only 60–70% in advanced stages, and even lower as a second-line treatment. Despite guideline recommendations, which drugs will be most effective remains unclear. Thus, a strateg...
cancer type [4,5,6,7]. Indeed, HGSTOC is characterised by very pronounced patterns of chromosomal instability, which are often highly distinct within the same tumour [7,8] or between their different metastatic localisations [9], but can often also change during disease progression [10]. In...
It has also been well documented that chemicals or anti-cancer gonadotoxic drugs are major inducers of sub-fertility in females before the physiological age, known as premature ovarian insufficiency (POI). In this regard, most POI patients derived to the fertility clinics have previously received ...
5525#Background:Improved long-term results can be achieved in advanced epithelial ovarian cancer (EOC) patients using optimal cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC).Methods:Indian society of peritoneal surface malignancy (ISPSM) is a registered body which ...
Multicellular dysregulation has an important function in the initiation and progression of a wide range of diseases, including cancer, where tumor development and accompanying immune responses depend on (and shape) the location of different cell-type populations, tissue properties and organization1,2,3...
MEF2A transcriptionally upregulates the expression of ZEB2 and CTNNB1 in colorectal cancer to promote tumor progression Qing Xiao Yaqi Gan Gang Yin Oncogene (2021) Norepinephrine-stimulated HSCs secrete sFRP1 to promote HCC progression following chronic stress via augmentation of a Wnt16B/β-cate...