Aberrant expression of N3-methylcytidine methyltransferase 2B (METTL2B) has been observed in various human malignancies, including those of the prostate, liver, breasts, and bladder. However, its role in ovarian cancer (OC) remains largely unexplored. This research preliminarily investigated METTL2B exp...
The Repertoire of Serous Ovarian Cancer Non-genetic Heterogeneity Revealed by Single-Cell Sequencing of Normal Fallopian Tube Epithelial Cells. Cancer Cell. 2020;37:226-242 e7. Article CAS PubMed Google Scholar Martincorena I, et al. Tumor evolution High burden and pervasive positive selection of...
Cancer-associated fibroblasts (CAFs), a dominant component of the pancreatic tumor microenvironment, are mainly considered as promotors of malignant progression, but the underlying molecular mechanism remains unclear. Here, we show that SDF-1 secreted by CAFs stimulates malignant progression and gemcitabin...
TWISTing stemness, inflammation and proliferation of epithelial ovarian cancer cells through MIR199A2/214. Oncogene. 29, 3545–3553. https://doi.org/10.1038/onc.2010.111 (2010). Article CAS PubMed PubMed Central Google Scholar Li, K. C. et al. Baculovirus-mediated miR-214 knockdown shifts...
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is the ninth member of the proprotein convertase family that regulates lipoprotein homeostasis and altered PCSK9 expression was reportedly associated with tumor development and progression. This study
Ovarian cancer frequently presents at an advanced stage and unusually, in contrast to other solid cancers, is treated with curative intent even in the presence of widespread peritoneal metastasis. We therefore investigate primary treatment and recurrent treatment separately. Show moreView article Hodgkin'...
Splicing factor USP39 promotes ovarian cancer malignancy through maintaining efficient splicing of oncogenic HMGA2. Cell Death Dis. 2021;12:294. Article PubMed PubMed Central Google Scholar Arango D, Sturgill D, Alhusaini N, Dillman AA, Sweet TJ, Hanson G, et al. Acetylation of cytidine in...
cancer, liver cancer, epithelial ovarian cancer, high-grade serous ovarian cancer and other cancers, and high expression of GBP1 is associated with better survival prognosis in these cancer patients [12,13,14,15]. On the other hand, a large number of studies have shown that the high ...
Women with untreated advanced breast cancer had a trend toward greater clinical benefit with fulvestrant (Faslodex) versus anastrozole (Arimidex) as first-line hormonal therapy, according to results from the FIRST (Fulvestrant First-Line Study Comparing Endocrine Treatments) randomized trial (Table). The...
Pancreatic cancer (PC) is one of the leading causes of cancer-related death worldwide due to delayed diagnosis and limited treatments. More than 90% of all pancreatic cancers are pancreatic ductal adenocarcinoma (PDAC). Extensive communication between tu