We classify such models according to the main homogenizing process: (a) clonal evolution models (ecological drift), (b) models of genetic isolation (gene flow), and (c) models of isolation by distance (spatial drift). We review these models and their specific predictions on macroscopic ...
Briefly explain how cancer arises through clonal evolution. Does genetic mutation cure cancer and diabetes? Explain. How do proto-oncogenes and tumor-suppressor genes regulate the cell cycle? How do mutations in the p53 gene affect cellular metabolism?
aIt combines the clonal selection theory and differential evolution and employs three operators: a clone operator, a differential mutation crossover mutation and a standard selection operator. 它结合无性系的选择理论和差别演变并且雇用三名操作员: 克隆操作员、一个有差别的变化天桥变化和一名标准选择操作员...
Dispersal and clonal diversity of North-European parthenogenetic earthworms At least 15 earthworm species are known to reproduce parthenogenetically. Most of these retain meiosis but the chromosome set is duplicated before meiosis;... J Terhivuo,A Saura - Springer Netherlands 被引量: 97发表: 2006年...
It might help to determine high risk patients for regular surveillance which is under discussion for achalasia patients and the spatiotemporal dynamics of clonal evolution occurring in achalasia might be potentially useful for optimization of endoscopic surveillance intervals in this group. BE is ...
Clonal chromosomal abnormalities in Fanconi's anaemia: what do they really mean? Summary. Patients with Fanconi's anaemia (FA) have aplastic anaemia, leukaemia, myelodysplasia and tumours. Since leukaemia has a very poor prognosis, it i... BP Alter,A Scalise,J Mccombs,... - 《British ...
A. et al. Evolution and impact of subclonal mutations in chronic lymphocytic leukemia. Cell 152, 714–726 (2013). CAS PubMed PubMed Central Google Scholar Calvete, O. et al. A mutation in the POT1 gene is responsible for cardiac angiosarcoma in TP53-negative Li-Fraumeni-like families....
35 Variation of signal intensity on T1-weighted images correlated with the degree of lesion inflammation, demyelination, and gliosis.36 Some insights into the pathophysiological correlates of lesion evolution were provided in a serial MRI study in which lesion development was followed with both Gd-...
Mouse models have thus been instrumental in achieving our current understanding of central tolerance, and the evolution of elegant model systems has led to an explosion of new data to be assimilated. This review will focus on recent advances in the field of clonal deletion with respect to three...
What is meant by the statement that "cancer is clonal?" Define chronic disease and give an example in humans. Define the following term: "auscultation". (a) Define the term acclimatization. (b) Give examples. What is the definition of physical fitness?