MAMI-reactive IFNγ+Teff in all tested patients contained a few highly expanded clonotypes (distinct TCRβ nucleotide sequences) with maximum frequencies at 6.8–26.7% (Fig.1dand Supplementary Fig.2b). Despite the small number of cells analyzed per patient, the measured proportion of each expande...
Repasky, in Progress in Molecular Biology and Translational Science, 2016 2.3 Clonal Evolution and Aberrant Cell Differentiation Create Subclonal Heterogeneity in AML 2.3.1 Clonal Evolution in AML AML is a prime example of clonal evolution in cancer, an iterative process of clonal cell expansion ...
different cell types3,4,5,6. Further, in sharp contrast with the massive expansion of individual, epitope-specific T and B cell clones, trained immunity is mostly described at the population level, as innate immune cell activation occurs via widely expressed pattern recognition receptors. More spe...
Plant clonality: Biology and diversity The current approaches to the study of clonal plants are reviewed. Most studies concentrate at the level of the ramet andclonal fragment exploring the R... Tomáš,Herben,Toshihiko,... - 《Folia Geobotanica》 被引量: 152发表: 1994年 ...
Longitudinal quantification of ZsG+ WT and ZsG+Tet2+/− clonal fractions in PB CD45+ leukocytes showed that, although both clonal fractions increase over time, there was a significantly higher expansion of the Tet2+/− clone compared with the WT (Figure 2B-C). Moreover, Tet2+/− ...
Genetic mutation provides cells with the potential to be positively selected and may ultimately lead to clonal dominance [39]. Malignant development may be induced if cells acquire substantial pro-survival mutations that confer unlimited growth and expansion [45]. Thus, understanding the acquisition and...
noltii maximize the rate of centrifugal expansion, maintaining a high density in colonized areas to produce close stands but also minimizing the investment in belowground biomass and ramets overlapping. The clonal architecture of Z. noltii seems to be regulated by the interaction of both, apical ...
In this paper, we present a comprehensive review of research on the ecological consequences of plant clonal integration based on a large body of literature... Fenghong,Liu,Jian,... - 《Frontiers in Plant Science》 被引量: 0发表: 2016年 CLONAL INTEGRATION AND THE EXPANSION OF PHRAGMITES AUSTR...
AML is a cancer of low mutation-burden4,5and thus provides an ideal model disease to investigate how mutations interact to promote and drive disease progression. Specific mutation combinations can be selected for during cancer development and drive clonal expansion because their co-occurrence improves...
while theConfetti-negative cells expressed the same level ofCcm3transcript as the wild-type endothelial cells (Supplementary Fig.3b). Overall, these data support the concept that, after the initial clonal expansion of a few endothelial cells that have undergone recombination, further development of ...