As the diversity of single-cell technology proliferated, the simultaneous conduction of multiple omics at the single-cell level (single-cell multiomics) came to the front, enabling a more precise definition of cellular characterization and comprehensive exploration of transcriptional regulatory mechanisms [...
4a). The strong association between the switching of alterations and key driver genes (EGFR, TP53, and PDGFRA) suggests (i) that some of these genes contribute to a late expansion, both in treated and untreated tumors, and (ii) that converging evolution is associated with these genes....
These data demonstrate the importance of clonal expansion, WGD and copy number instability in determining the timing and patterns of relapse in non-small cell lung cancer and provide a comprehensive clinical cancer evolutionary data resource.Similar content being viewed by others Evolutionary ...
in tumor-bearing mice, iTreg can contribute not only to the peripheral Treg pool but also to tumor-specific immune tolerance within the tumor tissue15,18. TC recognize their specific antigen through the
Copy number alterations (CNAs) are among the most important genetic events in cancer, but their detection from sequencing data is challenging because of unknown sample purity, tumor ploidy, and general intra-tumor heterogeneity. Here, we present CNAqc, a
E.Karjalainen,G.A.Repasky, inProgress in Molecular Biology and Translational Science, 2016 2.3.1Clonal Evolution in AML AMLis a prime example ofclonal evolutionin cancer, an iterative process of clonal cell expansion which includesgeneticand epigenetic diversification and clonal selection, requiring dyna...
a favored target for HIV infection [91]; it is likely these HIV specific cells persist during therapy, and that low level HIV production during cART may continue to drive persistence and expansion of these specific subsets. Other antigens commonly encountered (e.g., CMV, EBV) may also ...
(Figure S1A), we noted no effect on clonal expansion (Figure 1B) and found no evidence that Cxcr3 or Cxcr6 promoted Th1 differentiation, either by direct ex vivo interferon-γ (IFN-γ) production or co-expression of CCL5 and IFN-γ as a stricter definition of Th1 in our system (...
infiltrate multiple organs (Figures S5H–S5J). Taken together, these results show that the development and expansion of CD8+ Taa cells depend on cell-extrinsic age-related factors and that differentiated CD8+ Taa cells have a stable...
This PIK3CA mutant-driven resistance could be overcome by combination treatment with PI3K pathway inhibitors in vitro, providing a possible rationale for a combination treatment. There is no strict definition of a ‘subclonal’ mutation and studies to date have defined such mutations as alterations ...