B cell clonal expansion and affinity maturation takes place in germinal centers (GC) and is orchestrated by follicular T cells. Here authors show that naïve conventional T cells are continuously recruited to the GCs during the GC reaction and develop into follicular helper and regulatory T cells...
This chapter presents comments on clonal and nonclonal selection and expansion of B cells. Studies carried out in mice, rats, and rabbits have shown that after the injection of an antigen, two population of cells appeared: cells synthesizing and secreting antibodies directed against the antigen ...
We reasoned that subclones with an illusion of clonality in at least one tumour region may reflect a large subclonal expansion and therefore might exhibit a signal of positive selection. Consistent with this idea, in LUAD, we found evidence for significant subclonal selection (dN/dS = ...
. scDNA-seq revealed the clonal selection in AML patients treated with VEN, showing the clear clonal expansion of clones harboring RAS mutation [
29, 30, 31 This supports the hypothesis that, besides site-specific mutations, the expansion of resistant clones might play an important role for the development of TKI resistance in AML. In our study, we comprehensively investigated the clonal evolution of FLT3-ITD–positive AML in patients ...
If male function fitness is maximized under higher rates of clonal expansion than for female function, greater frequencies of male ramets might reflect the outcome of fertility selection, rather than constraints on clonal expansion imposed by greater costs of reproduction for females. This is a ...
we used only sequences of identical length, i.e., we removed the sequences that were different from the most common sequence length of a CF. The resulting lineage reflected all sequences that make up a CF and the SHM’s imposed on the B-cell receptors during clonal expansion. Each node...
Clonal Selection Algorithm with Search Space Expansion Scheme for Global Function Optimization. Y Sun,M Gong,L Hao,L Jiao. Lecture Notes in Computer Science . 2006Yifei Sun , Maoguo Gong , Lin Hao , Licheng Jiao, Clonal selection algorithm with search space expansion scheme for global function ...
Generating clonal populations. We devised a strategy to isolate chromatically diverse founder cells for clonal expansion. Our goal was to build a library of diversely color-coded clones with representative clonal color properties, which would also serve as potential participant clones in a multi...
found that resistance could emerge either from the expansion of cells with preexisting resistance mutations, or through the survival of a population of drug-tolerant persister cells18. In this latter case, drug-tolerant cells can survive but not proliferate in the presence of EGFR inhibitors; ...