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In neurons, voltage-gated sodium (Nav) channels underlie the generation and propagation of the action potential. The proper targeting and concentration of Nav channels at the axon initial segment (AIS) and at the nodes of Ranvier are therefore vital for neuronal function. In AIS and nodes, Nav...
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Voltage-gated sodium channels (VGSCs) are transmembrane proteins that increase the permeability of sodium ions across membranes. The permeability of these channels depends on the voltage drop across the membrane. In a typical neuronal action potential, VGSCs remain closed until the membrane potential ...
Functional expression of voltage-gated sodium channels Nav1.5 in human breast cancer cell line MDA-MB-231. J Huazhong Univ Sci Technolog Med Sci 2009;29:64-7.Gao, R., Wang, J., Shen, Y., Lei, M. & Wang, Z. (2009) Functional expression of voltage-gated sodium channels Nav1.5 in ...
Voltage-gated sodium (Nav) channels function as the main drivers of the depolarization phase of action potentials. As such, they are ubiquitously found in a wide range of excitable tissues, playing fundamental roles in many vital physiological functions, such as skeletal muscle contraction, heart be...
Voltage-gated sodium channels (NaV) are responsible for the rapid depolarization of many excitable cells. They readily inactivate, a process where currents diminish after milliseconds of channel opening. They are also targets for a multitude of disease-causing mutations, many of which have been shown...
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SodiumVoltage-gated Na+ (NaV) channels are key mediators of neuronal function and essential for neuronal excitability. Their abnormal activity is implicated in the generation of seizures, both in acquired and genetic epilepsy. Several of the most widely used antiepileptic drugs inhibit NaV activity ...
Furthermore,the external calcium was found to influx mainly through N-type calcium channels and voltage-gated sodium channels. 我们进一步用膜通道阻断剂验证,发现胞外钙的流入主要是通过N型钙通道和电压门控钠通道流入胞内的。 更多例句>> 4) voltage-gated sodium currents 电压门控钠通道电流 1. The...