Voltage-gated Na channels are responsible for the Na current that underlies the rapid upstroke of the action potential in nerve and muscle fibres. Mutations in sodium channel genes may therefore be expected to result in diseases of nerve and muscle, including cardiac muscle. In the mutations ...
Voltage-gated Na+ (NaV) channels are key mediators of neuronal function and essential for neuronal excitability. Their abnormal activity is implicated in the generation of seizures, both in acquired and genetic epilepsy. Several of the most widely used antiepileptic drugs inhibit NaV activity by ...
Tiwari JK, Sikdar SK 1998 Voltage gated Naϩ channels contribute to membrane voltage fluctuation in ␣T3-1 pi- tuitary gonadotroph cells. Neurosci ... JK Tiwari,SK Sikdar - 《Neuroscience Letters》 被引量: 8发表: 1998年 Voltage gated Na+ channels contribute to membrane voltage fluctuation...
The hinged-lid model was long accepted as the canonical model for fast inactivation in Nav channels. It predicts that the hydrophobic IFM motif acts intracellularly as the gating particle that binds and occludes the pore during fast inactivation. However
Voltage-gated Na+ channels in neuropathic pain. Neuropathic pain occurs as a result of some form of injury to the nervous system. Although the basis of the disease remains to be fully elucidated, numerou... NJ Hargus,MK Patel - 《Expert Opinion on Investigational Drugs》 被引量: 46发表: ...
Involvement of voltage-gated K+ and Na+ channels in gastric epithelial cell migration. Mol Cell Biochem. 2008;308(1-2):219-226.Wu WK, Li GR, Wong TM, Wang JY, Yu L, Cho CH. Involvement of voltage-gated K+ and Na + channels in gastric epithelial cell migration. Mol Cell ...
Na+ channels consist of a pore-forming α-subunit, as well as associated β-subunits. The family of related α-subunits consists of 10 members, 9 of which (Nav1.1–1.9) are voltage gated and one further non-voltage-gated member, Nax, which is involved in salt sensing. Nav1.1, Nav1.6,...
Voltage-sensing domains control the activation of voltage-gated ion channels, with a few exceptions1. One such exception is the sperm-specific Na+/H+ exchanger SLC9C1, which is the only known transporter to be regulated by voltage-sensing domains2–5. Af
Mammalian species express nine functional voltage-gated Na+ channels. Three of them, the cardiac-specific isoform Nav1.5 and the neuronal isoforms Nav1.8 and Nav1.9, are relatively resistant to the neurotoxin tetrodotoxin (TTX; IC50 ⩾1 μM). The other six isoforms are highly sensitive to TTX...
Armed with these tools, researchers have made increasingly dramatic discoveries about sodium channels, culminating most recently in crystal structures of voltage-gated sodium channels from bacteria. These structures, along with those from other channels, give unprecedented insight into the structural basis ...