Voltage-gated Na channels are responsible for the Na current that underlies the rapid upstroke of the action potential in nerve and muscle fibres. Mutations in sodium channel genes may therefore be expected to result in diseases of nerve and muscle, including cardiac muscle. In the mutations...
Voltage-gated Na+ (NaV) channels are key mediators of neuronal function and essential for neuronal excitability. Their abnormal activity is implicated in the generation of seizures, both in acquired and genetic epilepsy. Several of the most widely used antiepileptic drugs inhibit NaV activity by ...
Voltage-gated Na + channels in chemoreceptor afferent neurons—Potential roles and changes with development ☆Carotid bodyNa+ channel... Donnelly,F David - 《Respiratory Physiology & Neurobiology》 被引量: 3发表: 2013年 Enteroendocrine cells: a site of 'taste' in gastrointestinal chemosensing. PURPO...
Na+ channels consist of a pore-forming α-subunit, as well as associated β-subunits. The family of related α-subunits consists of 10 members, 9 of which (Nav1.1–1.9) are voltage gated and one further non-voltage-gated member, Nax, which is involved in salt sensing. Nav1.1, Nav1.6,...
Voltage- gated Na+ channel activity and connexin expression in Cx43- deficient cardiac myocytes [In Process Citation]. J Cardiovasc Electrophysiol 1999;10:1390-1401.Johnson CM, Green KG, Kanter EM, Bou-Abboud E, Saffitz JE, Yamada KA. Voltage-gated Na + channel activity and connexin ...
Voltage-gated Na(+) channels are heteromeric membrane glycoproteins responsible for the generation of action potentials. A number of diverse lipid-soluble ... SY Wang,GK Wang - 《Cellular Signalling》 被引量: 569发表: 2003年 Voltage-gated sodium channels as therapeutic targets in epilepsy and oth...
Armed with these tools, researchers have made increasingly dramatic discoveries about sodium channels, culminating most recently in crystal structures of voltage-gated sodium channels from bacteria. These structures, along with those from other channels, give unprecedented insight into the structural basis ...
Voltage-gated sodium channels and metastatic disease Voltage-gated Na+ channels (VGSCs) are macromolecular protein complexes containing a pore-forming α subunit and smaller non-pore-forming β subunits. VGSC... Brackenbury,J William - 《Channels》 被引量: 145发表: 2012年 Slow inactivation in v...
Channel proteins (such as the voltage-gated Na channel) transport ions much faster than carrier proteins (such as the Na-K pump), but they cannot be coupled to an energy source; therefore, transport mediated by channels is always passive. A.正确B.错误 相关知识点: 试题来源: 解析 A 反...
The hinged-lid model was long accepted as the canonical model for fast inactivation in Nav channels. It predicts that the hydrophobic IFM motif acts intracellularly as the gating particle that binds and occludes the pore during fast inactivation. However