Ion Channel GatingMolecular StructureProtein ConformationThe voltage-sensitive ion channels are responsible for generation of conducted action potentials in excitable cells and for a wide range of regulatory events in nonexcitable cells. On depolarization, permeability to sodium, calcium, or potassium ...
Voltage-gated sodium (Na+) channels (VGSCs) are complex, transmembrane proteins that have a role in governing electrical activity in excitable tissues. The Na+ channel is activated in response to depolarization of the cell membrane that causes a voltage-dependent conformational change in the channel...
These results suggest, as already described for the cardiac voltage-gated sodium channel Nav1.5, that a mutant of the Cavα1 subunit may lead to an “overlap” syndrome. Brugada syndrome is a genetic disease that is characterized by an abnormal electrocardiogram that increases the risk of sudden...
Voltage-gated sodium channel genes,SCNXA, encode for the four domains channel3unlike voltage-gated potassium channel genes, which encode for one domain of the pore assembling as a tetramer. However, characterization of severalSCN5Amutations have led to mounting evidence questioning the stoichiometry of...
Voltage-gated sodium channels are protein complexes comprised of one pore forming α subunit and two, non-pore forming, β subunits. The voltage-gated sodium channel β subunits were originally identified to function as auxiliary subunits, which modulate the gating, kinetics, and localization of the...
(2006). The voltage-gated sodium channel NaV1.9 is an effector of peripheral inflammatory pain hypersensitivity. J. Neurosci. 26, 12852–12860.10.1523/JNEUROSCI.4015-06.2006Search in Google Scholar Blair, N.T., and Bean, B.P. (2003). Role of tetrodotoxin-resistant Na+ current slow ...
Voltage-gated sodium channels (NaV) are responsible for the rapid depolarization of many excitable cells. They readily inactivate, a process where currents diminish after milliseconds of channel opening. They are also targets for a multitude of disease-causing mutations, many of which have been shown...
Voltage-gated sodium channels (VGSCs) play a central role in the generation and propagation of action potentials in neurons and other cells. VGSC modulators have their origins in empirical pharmacology and are being used as local anaesthetics, antiarrhythmics, analgesics and antiepileptics, and for ...
Multiple voltage-gated Na+ (Nav) channelopathies can be ascribed to subtle changes in the Nav macromolecular complex. Fibroblast growth factor 14 (FGF14) is a functionally relevant component of the Nav1.6 channel complex, a causative link to spinocerebel
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