Again, calling out the unique properties of the ErbB family of RTKs – the kinase activity of these receptors is activated through a unique allosteric mechanism whereby the C-lobe of one kinase domain in the dimer pair (the so called ‘activator’ kinase) physically contacts the N-lobe of t...
With these prospects, interest in this new class of therapeutics extends from basic research scientists to practicing oncologists and their patients. An extension of the initial successes in molecular oncology will occur more quickly and successfully through an appreciation of lessons learned with the ...
Receptor tyrosine kinases are a subclass of cell-surface growth-factor receptors with an intrinsic, ligand-controlled tyrosine-kinase activity. They regulate diverse functions in normal cells and have a crucial role in oncogenesis. Twenty years ago, the first primary structure of a receptor tyrosine...
Non-small-cell lung cancer (NSCLC) cells with somatic mutations in epidermal growth factor receptors (EGFR) are initially susceptible to tyrosine kinase in... W Meng,J Zhao,LM Zhang,... - 《Journal of Cancer Research & Clinical Oncology》 被引量: 54发表: 2012年 Mice lacking Axl and Mer...
The authors also discuss the critical methodologic aspects of the molecular assays used for the selection of tyrosine kinase treatment for oncology patients. Cancer (Cancer Cytopathol) 2013. © 2012 American Cancer Society. 展开 关键词: molecular diagnostics genomic medicine cancer-targeted therapies ...
Receptors Tyrosine Kinases References 1. Lemmon MA, Schlessinger J. Cell signaling by receptor tyrosine kinases [J].Cell,2010 ,141(7):1117-34. 2. Bennasroune A, et al. Tyrosine kinase receptors as attractive targets of cancer therapy[J]. Critical reviews in oncology/hematology, 2004, 50(1...
Since their invention in the early 2000s, tyrosine kinase inhibitors (TKIs) have gained prominence as the most effective pathway-directed anti-cancer agents. TKIs have shown significant utility in the treatment of multiple hematological malignancies and
In some receptors (e.g., insulin, FGF), the catalytic domain is split by a non-tyrosine kinase sequence. Examples of N-terminal region motifs include cysteine rich sequences (gold), fibronectin type III-like regions (green), a series of IgG (immunogammaglobulin; blue) regions, and the ...
Background and purpose:TrkB,a neurotrophic tyrosine kinase receptor,serves as a potent and specific suppressor of anoikis of non-malignant epithelial cells,and induces high invasion capacity in these cells.TrkB over-expression has been associated with chemotherapy resistance and poor survival in neuroblas...
Tropomyosin receptor kinase (TRK) refers to the neurotrophin receptor tyrosine kinase genes NTRK1/2/3 and their respective encoding neurotrophin protein receptors TRKA/B/C. TRK signal pathways play crucial roles in neuronal development and differentiation. Fusions involving NTRK1/2/3 are the most com...