属于酪氨酸激酶连接的受体(tyrosine kinase associated receptor)。细胞因子(cytokine),如:白介素(IL)、干扰素(IFN…waqizhong.blog.163.com|基于26个网页 2. 型受体 酪氨酸激酶结合型受体(tyrosine kinase associated receptor)与前一类受体不同,受体分子本身没有蛋白激酶活性,但一旦与配 …mpd123.blog.163.com|基...
Receptor for bombesin with associated tyrosine kinase activity. Mol Cell Biol. 1986 Dec; 6 (12):4641–4649.Cirillo DM, Gaudino G, Naldini L, Comoglio PM. Receptor for bombesin with associated tyrosine kinase activity. Mol Cell Biol. 1986 Dec; 6 (12):4641–4649. [ PMC free article ] [...
95,96]. The importance of identifying these chromosomal rearrangements and the ensuing tyrosine kinase fusion is underscored by that fact that these aberrant fusion proteins are often therapeutically targetable with small molecule inhibitors. The first...
Box 1. Principles of tyrosine kinase inhibition in cancer therapy Receptor tyrosine kinases comprise a large family in the human genome and are important mediators of extracellular signals into the cell. A wide variety of receptor tyrosine kinases have been associated with malignant properties, repre...
Receptor tyrosine kinase inhibitors improve cancer survival but their cardiotoxicity requires investigation. We investigated these inhibitors’ effects on human cardiac progenitor cells in vitro and rat heart in vivo. We applied imatinib, sunitinib or so
Caveolin 1-Mediated Regulation of Receptor Tyrosine Kinase-Associated Phosphatidylinositol 3-Kinase Activity by Ceramide Previous studies have indicated that proapoptotic stresses downregulate the phosphatidylinositol 3-kinase [PI(3)K]/Akt survival pathway via the activation ... Wayne,Zundel,Lillian,... ...
Recently, however, the discovery that the insulin receptor is associated with an insulin-dependent protein kinase activity (Kasuga et al ., 1982a,b,c; Petruzzelli et al ., 1982; Van Obberghen and Kowalski, 1982; Haring et al ., 1982; Zick et al ., 1983a,b; Avruch et al ., ...
Yes-associated protein 1 (YAP1), a nuclear effector of the Hippo pathway, plays an important role in tumorigenesis and progression of multiple cancers. The present study aimed to investigate the clinical significance of YAP1 and receptor tyrosine kinase Axl expression in human lung adenocarcinomas ...
Another target opportunity for ADCs among receptor tyrosine kinases is represented by AXL, a member of the TYRO3, AXL and MERTK (TAM) family, associated with the switching from a proliferative to an invasive tumor phenotype, epithelial-mesenchymal transition (EMT), and ...
Receptor Tyrosine Kinase Inhibitors are molecules that block the activity of specific receptors involved in neuroinflammatory processes, which can contribute to the progression of Alzheimer's disease by preventing the overactivation of these receptors. ...