Breast cancer is a multifactorial disease and driven by aberrant regulation of cell signaling pathways due to the acquisition of genetic and epigenetic changes. An array of growth factors and their receptors is involved in cancer development and metastasis.ReceptorTyrosineKinases (RTKs) constitute a ...
However, unlike multiple other ectopically expressed receptor tyrosine kinases including full-length EGFR or an EGFR/Axl chimera, the Mer chimera did not stimulate proliferation. Moreover, and in contrast to EGFR,Mer chimera activation induced adherence and cell flattening in the normally suspension-...
A number of different intracellular signaling pathways have been shown to be activated by receptor tyrosine kinases. These activation events include the phosphoinositide 3-kinase, 70 kDa S6 kinase, mitogen-activated protein kinase (MAPK), phospholipase C-γ, and the Jak/STAT pathways. The precise ...
Receptor tyrosine kinases are a diverse group of transmembrane proteins that act as receptors for cytokines, growth factors, hormones and other signaling molecules. Receptor tyrosine kinase (RTK) is part of the larger family of protein tyrosine kinase. Receptor tyrosine kinases have been shown to pla...
Receptor tyrosine kinases activate canonical WNT/β-catenin signaling via MAP kinase/LRP6 pathway and direct β-catenin phosphorylation. PLoS ONE 7, e35826.Krejci, P., Aklian, A., Kaucka, M., Sevcikova, E., Prochazkova, J., Masek, J. K., et al. (2012). Receptor tyrosine kinases ...
Recept r Tyr sine Kinase Di erizati n and Kinase Activati n Top: In general, receptor tyrosine kinases (RTKs) associate into dimers when ligand (red) binds to their extracellular regions. The bound ligand can orm all, a portion, or none o the dimer inter ace, and it activates the ...
Receptor tyrosine kinases (RTKs) play an important role in a variety of cellular processes including growth, motility, differentiation, and metabolism. As such, dysregulation of RTK signaling leads to an assortment of human diseases, most notably, cancers. Recent large-scale genomic studies have rev...
Ufo/Axl belongs to a new family of receptor tyrosine kinases with an extracellular structure similar to that of neural cell adhesion molecules. In order to... Braunger,Jürgen,Schleithoff,... - 《Oncogene》 被引量: 228发表: 1997年 Cell signaling by receptor tyrosine kinases: from bench to ...
Cell signaling by receptor tyrosine kinases. Cell 141, 1117–1134 (2010). Article CAS PubMed PubMed Central Google Scholar Armstrong, F. et al. Differential effects of X-ALK fusion proteins on proliferation, transformation, and invasion properties of NIH3T3 cells. Oncogene 23, 6071–6082 (...
L., and Y. Yarden (Editors), 2015 Receptor Tyrosine Kinases: Structure, Functions and Role in Human. Humana Press Springer, New York.D. L. Wheeler and Y. Yarden, Receptor Tyrosine Kinases: Structure, Functions and Role in Human Disease, Springer, 2014....