Receptor tyrosine kinases (RTKs) comprise a large family of cell surface receptors that control many critical cellular processes. It is now well established that various human diseases and pathologies are caused by dysfunction in RTKs or in the intracellular signaling pathways that they activate. ...
LeadingEdge Review Cell141,June25,2010©2010ElsevierInc.1117 Sincethediscoveryo therstreceptortyrosinekinase(RTK)more thanaquartero acenturyago,manymemberso this amilyo cell-sur acereceptorshaveemergedaskeyregulatorso critical cellularprocesses,suchasproli erationanddi erentiation,cell survivaland...
The EML4-ALK oncogene forms cytoplasmic protein condensates that are associated with its oncogenic signaling. Here, the authors demonstrate that these EML4-ALK assemblies also sequester receptor tyrosine kinase (RTK) adapter proteins suppressing signaling which was reversed upon ALK inhibition, resulting in...
Abstract PL04-03: Cell signaling by receptor tyrosine kinases: From basic principles to cancer therapy Receptor tyrosine kinases (RTKs) comprise a family of cell surface receptors that control many critical cellular processes. Various human diseases are caus... J Schlessinger - 《Environment & Ecolo...
For example, the protein encoded by the ERBB4 gene is a receptor tyrosine kinase, which had been known to regulate cell proliferation and differentiation56. In fact, as the initial responders of intracellular signaling pathways, receptor kinases can function as the upstream of TFs and thus play ...
受体酪氨酸激酶(Receptor tyrosine kinases,RTKs)是最大的一类酶联受体, 它既是受体又是酶。在未与信号分子结合时以单体存在,并且没有活性;一旦有信号分子与受体的细胞外结构域结合,两个单体将在膜上形成二聚体,两个受体的细胞内结构域的尾部相互接触,激活它们的蛋白激酶活性,使尾部的酪氨酸残基磷酸化;随后,多个...
SignalingReceptor •Acelltargetedbyaparticularchemicalsignalhasareceptorproteinthatrecognizesthesignalmolecule.•Theresponseofaparticularcelltoasignaldependsonthetypeofproteinsitcontains.CellReceptors Cellsurfacereceptors •Cellsurfacereceptors(membranereceptors,transmembranereceptors)arespecializedintegralmembraneproteins...
受体酪氨酸激酶(Receptor tyrosine kinases,RTKs)是最大的一类酶联受体, 它既是受体又是酶。在未与信号分子结合时以单体存在,并且没有活性;一旦有信号分子与受体的细胞外结构域结合,两个单体将在膜上形成二聚体,两个受体的细胞内结构域的...
by receptor tyrosine kinases involves coordinated action of ubiquitin ligases (i.e. Cbl), adaptor proteins (i.e. Grb2 and CIN85), inhibitory molecules (i.e. Sprouty), cytoplasmic kinases (i.e. activated Cdc42-associated kinase) and phosphoinositol metabolites. These inhibitory signals are ...
G-protein-coupled receptors and protein tyrosine kinases represent two prominent pathways for cellular signaling. As our knowledge of cell signaling pathways mediated by the superfamily of G-protein-coupled receptors and the smaller family of receptor tyrosine kinases expands, so does our appreciation of...