Receptor tyrosine kinase related pathways were highlighted in red. P-values were calculated by two-sided nonparametric permutation test and adjusted by the false discovery rate (q-value). (c, d) The expression of EGFR, PDGFRA, KIT, and MET mRNA level between SNF4 (n = 34) and other...
The purpose of this study was to prove the presence of NGF (nerve growth factor) and its receptor TrkA (tyrosine kinase receptor) with immunofluorescence. The peri/articular tissues were harvested from the lumbar facet joints of ten patients surgically treated for degenerative diseases. There were ...
In comparison to PN GSCs, we found significant upregulation and phosphorylation of the receptor tyrosine kinase AXL in MES GSCs. Knockdown of AXL significantly decreased MES GSC self-renewal capacity in vitro and inhibited the growth of glioblastoma patient-derived xenografts. Moreover, inhibition of...
In this study, cell-based evaluation showed that MP470, a novel tyrosine kinase inhibitor inhibited cell proliferation, induced growth arrest and promoted apoptosis in prostate cancer cells. In addition, the combination treatment of MP470 and Erlotinib completely inhibited HER family activation, and ...
Insulin binds and activates a receptor tyrosine kinase, the insulin receptor (IR), at the cell surface1,2,3. The activated IR triggers signaling cascades to control many facets of physiology. Dysfunctional IR signaling causes metabolic disorders such as diabetes, a heterogenous disease whose treatme...
Insulin receptor (IR) is a receptor tyrosine kinase that plays critical roles in cellular signaling, growth, and metabolism1,2,3,4,5,6,7,8,9,10. IR can be activated by two highly related ligands – insulin and insulin-like growth factor 2 (IGF2)11,12. Insulin and IGF2 share high ...
Neither the diffusion nor the residency time at excitatory synapses of EphB2 tyrosine kinase receptors (EphB2Rs) or voltage-gated potassium channels KV1.3 were affected by prolonged exposure to KET (Figures S3A and S3B). Likewise, the diffusion, residency time and surface explored by γ2 ...
The invention relates to methods of evaluating the specific function of a receptor protein tyrosine kinase in cells. The methods activate the receptor in a ligand independent fashion. In addition, the
Oncogenic membrane receptor tyrosine kinases such as MET and EGFR, or auto-active variants thereof, are important targets for cancer precision therapy. Targeted inhibition of these oncogenic receptors however invariably leads to resistance, resulting fro
Sigma mAb, 1:100 dilution) in 2 HPCa (i.e., HPCa90 and HPCa139) and matched benign tissues. Enlarged images of boxed regions are shown on the right. Scale bars are indicated in one representative whole-mount (left) and enlarged (right) image, respectively. Inf, whole-mount slides were...