Receptor tyrosine kinases (RTKs) comprise a large family of cell surface receptors that control many critical cellular processes. It is now well established that various human diseases and pathologies are caused by dysfunction in RTKs or in the intracellular signaling pathways that they activate. ...
Recept r Tyr sine Kinase Di erizati n and Kinase Activati n Top: In general, receptor tyrosine kinases (RTKs) associate into dimers when ligand (red) binds to their extracellular regions. The bound ligand can orm all, a portion, or none o the dimer inter ace, and it activates the ...
Cell signaling by receptor tyrosine kinases: from bench to bedside. Receptor tyrosine kinases (RTKs) comprise a large family of cell surface receptors that control many critical cellular processes. It is now well establishe... Schlessinger,Joseph - 《Faseb Journal》 被引量: 185发表: 2007年 Nucl...
Cell signaling by receptor tyrosine kinases. Cell 141, 1117–1134 (2010). CAS PubMed PubMed Central Google Scholar Trenker, R. & Jura, N. Receptor tyrosine kinase activation: from the ligand perspective. Cell Signal. 63, 174–185 (2020). CAS Google Scholar Müller, D. J. et al. ...
Lemmon MA, Schlessinger J: Cell signaling by receptor tyrosine kinases. Cell. 2010, 141: 1117-1134. 10.1016/j.cell.2010.06.011. Article CAS PubMed Central PubMed Google Scholar Baselga J: Targeting tyrosine kinases in cancer: the second wave. Science. 2006, 312: 1175-1178. 10.1126/scienc...
A number of different intracellular signaling pathways have been shown to be activated by receptor tyrosine kinases. These activation events include the phosphoinositide 3-kinase, 70 kDa S6 kinase, mitogen-activated protein kinase (MAPK), phospholipase C-γ, and the Jak/STAT pathways. The precise ...
Artificial MET receptor agonists such as macrocyclic peptides have the potential to be developed as novel biological drugs manufactured by chemical synthesis. Finally, RaPID selection can be applied to various membrane proteins40,41,42,43, including other receptor tyrosine kinases, so that we will ...
SH2 domain-mediated interactions representa crucial step in transmembrane signaling by receptor tyrosine kinases. SH2 domains recognize phosphotyrosine (pY) in the context of particular sequence motifs in receptor phosphorylation sites. However, the modest binding affinity of SH2 domains to pY containing...
However, unlike multiple other ectopically expressed receptor tyrosine kinases including full-length EGFR or an EGFR/Axl chimera, the Mer chimera did not stimulate proliferation. Moreover, and in contrast to EGFR,Mer chimera activation induced adherence and cell flattening in the normally suspension-...
Receptor Tyrosine Kinases Activate Canonical WNT/β-Catenin Signaling via MAP Kinase/LRP6 Pathway and Direct β-Catenin Phosphorylation.Receptor Tyrosine Kinases Activate Canonical WNT/β-Catenin Signaling via MAP Kinase/LRP6 Pathway and Direct β-Catenin Phosphorylation.doi:10.1371/journal.pone.0035826Recept...