Nerve growth factor (NGF ) can influence mast cell development and function in murine rodents by interacting with its receptors on mast cells. We now report the identification of mRNA transcripts of full-length tyrosine kinase-containing trk A, trk B, and trk C neurotrophin receptor genes in ...
which is important formacrophage function, is another example of an RTK ligand. RTKs can function asmonomersor multimeric subunits assembled at the plasma membrane that, uponligand binding, causeoligomerizationor conformational changes followed by tyrosine (trans)-phosphorylation in the kinase activation ...
Despite the diversity of tyrosine kinase fusions which have been described, the structure of the resultant fusion oncoproteins retains a remarkable similarity. Fusions may occur in either the N-terminal or the C-terminal of the RTK, with the TKD preserved in both cases (Fig.2a). If the genomi...
The mer receptor tyrosine kinase: expression and function suggest a role in innate immunity (p 2160-2167) P, Gong, SY, Garrett, S, Stein, PL, Cohen, PL (2003) The mer receptor tyrosine kinase: expression and function suggest a role in innate immunity... - 《European Journal of Immunolog...
1.Receptortyrosinekinase(RTK) 2.Tyrosine-kinase-associatedreceptors 3.Rceptorliketyrosinephosphatases 4.ReceptorSer/Thrkinases 5.Receptorguanylylcyclases 6.Histidine-kinase-associatedreceptors 4 1、Receptortyrosinekinasesignalingpathway —RTKsignalingpathwayshaveawidespectrumoffunctions includingregulationofcellprolife...
The common activation of ALK has led to the use of the ALK tyrosine kinase inhibitor (TKI) crizotinib in a range of patient populations and to the rapid development of second-generation drugs targeting ALK. In this Review, we discuss our current understanding of ALK function in human cancer ...
Expression, Function and Activation of the Proto-oncogene c-kit Product in Human Leukemia Cells The c-kil proto-oncogene encodes a receptor tyrosine kinase that is considered to play important roles in hematopoiesis. The proto-oncogene c-kit product i... Y Kanakura,H Ikeda,H Kitayama,... -...
Receptor tyrosine kinase (RTK) inhibitors targeting VEGF receptor is one of the most promising agents. 血管内皮细胞生长因子 (VEGF)是体内活性最强、专属性最高的促血管生成因子 ,故成为寻找血管生成抑制剂的重要靶点 ,其中靶向 VEGF受体酪氨酸激酶的抑制剂令人最为关注。 2. Our study is aimed to investig...
The Axl receptor tyrosine kinase is a discriminator of macrophage function in the inflamed lung. 来自 Nature 喜欢 0 阅读量: 10 作者:Fujimori,A M,Grabiec,Kaur,T J,Bell,Fujino,P C,Cook,F R 摘要: Much of the biology surrounding macrophage functional specificity has arisen through examining ...
Receptor tyrosine kinases (RTKs) are highly regulated, single pass transmembrane proteins, fundamental to cellular function and survival. Aberrancies in regulation lead to corruption of signal transduction and a range of pathological outcomes. Although control mechanisms associated with the receptors and ...