Receptor tyrosine kinases (RTKs) are transmembrane receptors of great clinical interest due to their role in disease, notably cancer. Since their discovery, several mechanisms of RTK dysregulation have been identified, resulting in multiple cancer types displaying 'oncogenic addiction' to RTKs. As a...
Gschwind A,Fischer OM,Ullrich A.The discovery of receptor tyrosine kinases: targets for cancer therapy. Nature Reviews Cancer . 2004Gschwind A, Fischer OM, Ullrich A. The discovery of receptor tyrosine kinases: targets for cancer therapy. Nat Rev Cancer 2004;4;361-70....
Receptor tyrosine kinases (RTKs) are a subclass of tyrosine kinases that are involved in mediating cell-to-cell communication and controlling a wide range of complex biological functions, including cell growth, motility, differentiation, and metabolism. There are 58 known RTKs in humans [1,2], ...
Box 1. Principles of tyrosine kinase inhibition in cancer therapy Receptor tyrosine kinases comprise a large family in the human genome and are important mediators of extracellular signals into the cell. A wide variety of receptor tyrosine kinases have been associated with malignant properties, repre...
Thyroid cancer is frequently associated with the oncogenic conversion of receptor tyrosine kinases (RTKs) or their downstream signalling molecules. Hence, there is a strong biological rationale for assessing the efficacy of RTK blockade to treat patients who are resistant to or not candidates for trea...
Receptor Tyrosine Kinase-Targeted Cancer Therapy. In the past two decades, several molecular targeted inhibitors have been developed and evaluated clinically to improve the survival of patients with cancer... Toshimitsu,Yamaoka,Sojiro,... - 《International Journal of Molecular Sciences》 被引量: 4发表...
Receptors Tyrosine Kinases References 1. Lemmon MA, Schlessinger J. Cell signaling by receptor tyrosine kinases [J].Cell,2010 ,141(7):1117-34. 2. Bennasroune A, et al. Tyrosine kinase receptors as attractive targets of cancer therapy[J]. Critical reviews in oncology/hematology, 2004, 50(1...
Bartolotti M, Franceschi E, Brandes AA (2012) EGF receptor tyrosine kinase inhibitors in the treatment of brain metastases from non-small-cell lung cancer. Expert Rev Anticancer Ther 12:1429–1435. : 10.1586/era.12.121
Receptor tyrosine kinases in PI3K signaling: the therapeutic targets in cancer 来自 Semantic Scholar 喜欢 0 阅读量: 40 作者:W Jiang,M Ji 摘要: The phosphoinositide 3-kinase (PI3K) pathway, one of the most commonly activated signaling pathways in human cancers, plays a crucial role in the ...
The EPHB4 receptor tyrosine kinase (RTK) has recently emerged as an oncogenic factor in many cancers, including lung cancer. Mutations ofin lung cancers have previously been identified, though their significance remains unknown. Here, we report the identification of novelmutations that lead to ...