BRCA-1 mutation-associated triple-negative breast cancer (TNBC) has been hypothesized to exhibit a phenotype that is distinct from non-mutation carriers. We have analyzed immunohistochemically detected cytokeratins 5 and 14, epidermal growth factor receptor (EGFR), claudin (CLDN) 3, 4, and 7, ...
A high cholesterol diet has been shown to induce angiogenesis and accelerate mammary tumor growth in a mouse model of triple negative breast cancer. Systemic inflammation has been shown to increase the metastatic behavior of triple negative breast cancer cells. One study found that 48% of BRCA1 ...
Faculty of Medicine, University of Southampton, Southampton University Hospitals NHS Trust, Southampton SO16 6YD, UK; 7Breakthrough Breast Cancer Research Unit, King's College, London SE1 9RT, UK BACKGROUND: Triple-negative (TN) tumours are the predominant breast cancer subtype in BRCA1 mutation...
Differential Claudin 3 and EGFR Expression Predicts BRCA1 Mutation in Triple-Negative Breast Cancerdoi:10.1080/07357907.2018.1499934Sabine DanzingerYen Yen TanMargaretha RudasMarie-Theres KastnerSigrid WeingartshoferDaniela MuhrChristian F. SingerkConFab Investigators...
miR-638 expression was significantly downregulated in breast cancer cell lines compared to the immortalized MCF-10A epithelial cells. BRCA1 was predicted as one of the direct targets of miR-638, which was subsequently confirmed by dual-luciferase reporter assay. Forced expression of miR-638 resulted...
[translate] aPrognostic role of BRCA1 mutation in patients with triple-negative breast cancer. BRCA1 变化的预兆的作用在有三倍消极的乳腺癌的病人中。[translate]
In this context, TNBC is usually found in cases of familial breast cancer; approximately 50% of cases demonstrate BRCA1/2 mutations, which can disrupt DNA repair pathways [91]. Four PARPIs have been currently approved by the FDA of the United States, namely olaparib, rucaparib, niraparib,...
It shows substantial overlap with basal-type and BRCA1-related breast cancers, both of which also have aggressive clinical courses. However, this overlap is not complete, and the expression of ER, PR, and HER2 has been noted in basal-like tumors. TNBC also includes the normal-like subtype,...
gBRCA1/2-mutated metastatic patients with nearly identical results4. TPC in both trials did not include standard first-line drugs, particularly platinums, but regardless these lower-toxicity non-chemotherapy options are hugely valuable both in TNBC and non-TNBC gBRCA-associated breast cancer. ...
aCurrent strategy for triple-negative breast cancer: appropriate combination of surgery, radiation, and chemotherapy. 当前战略为三倍消极乳腺癌: 手术、辐射和化疗的适当的组合。[translate] aturn up the voice 出现声音[translate] aClinical outcome of triple negative breast cancer in BRCA1 mutation carrier...