The majority of BRCA1 tumours are TNBC. TNBC has a worse prognosis and tends to relapse early compared with other subtypes of breast cancer. Conversely, it displays increased chemosensitivity compared with other breast tumour subtypes. Several agents are currently being investigated as potential ...
Adjuvant PARP inhibitors are given for those with germline BRCA1 or 2 mutations and capecitabine for those with residual disease, although optimal integration in the immunotherapy era is uncertain. In blue neoadjuvant treatment; in green adjuvant treatments. *only for germline carriers of BRCA1-2 mu...
(Breast Cancer Research, 2012) across HRDetect groups stratified by BRCA status. HRDetect-inter, intermediate subgroup; BRCA1pm, BRCA1 promoter hypermethylated; BRCAgerm, BRCA1/2 germline carriers; BRCAsom, BRCA1/2 somatic cases. b, Distribution of patient age (left), Ki67 staining (%, center...
The majority of BRCA1 tumours are TNBC. TNBC has a worse prognosis and tends to relapse early compared with other subtypes of breast cancer. Conversely, it displays increased chemosensitivity compared with other breast tumour subtypes. Several agents are currently being investigated as potential ...
Interestingly, the spectrum of p53 mutations among BRCA1-mutated TNBC is distinct from that occurring in sporadic TNBC [89]. The ataxia–telangiectasia-mutated kinase is aberrantly reduced similarly in both BRCA1-mutant (33%) and BRCA2-mutant (30%) hereditary BCs as well as in sporadic TNBC ...
Genetic evaluation of BRCA1 associated a complex genes with triple-negative breast cancer susceptibility in Chinese women[J]. Oncotarget, 2016, 7(9): 9759-9772. doi: 10.18632/oncotarget.7112 [46] Su CH, Chang WS, Hu PS, et al. Contribution of DNA Double-strand Break Repair Gene XRCC3...
Tumour Biol., 37 (8) (2016), pp. 11397-11407 CrossrefView in ScopusGoogle Scholar [35] P.S. Thiagarajan, et al. Cx26 drives self-renewal in triple-negative breast cancer via interaction with NANOG and focal adhesion kinase Nat. Commun., 9 (1) (2018), p. 578 View in ScopusGoogle...
Patients with basal subtypes of cancer with BRCA1 mutations have a poor prognosis (9). Based on specific gene expression patterns, breast cancers are categorized into five intrinsic or molecular subtypes. Among the intrinsic subtypes, basal-like triple-negative breast cancer (TNBC) accounts for 12...
The BRCA test germline was benign (BRCA1: C.4884T > C p.M1628T heterozygous mutation, germline, etc., benign mutation, BRCA2c.3396A > G p.K1132 = heterozygous mutation germline, etc., benign mutation). The diagnosis was triple negative adenocarcinoma of the right brea...
Clinical information of 1,069 female breast cancer patients in The Cancer Genome Atlas Breast Cancer cohort (TCGA-BRCA) were obtained from Pan-Cancer Clinical Data Resource23and RNA-sequencing data were obtained through cBio Cancer Genomic Portal24, we previously reported25,26. We also obtained cli...