With the introduction of new agents such as poly (adenosine diphosphate ribose) polymerase (PARP) inhibitors, immune-checkpoint inhibitors (ICIs), and trastuzumab deruxtecan, the range of effective treatment options for patients with metastatic triple negative breast cancer (mTNBC) has considerably ...
TNBC, triple-negative breast cancer; BC, breast cancer; BCT, conservative surgery; CHT, chemotherapy; DFS, disease-free survival; LR, local relapse; DR, distant relapse; RT, radiotherapy; OS, overall survival; CMF, cyclophosphamide–methotrexate–5-fluorouracil; BLBC, basal-like breast cancer; PF...
Triple-negative breast cancer (TNBC), a highly aggressive subtype of breast cancer, negatively expresses estrogen receptor, progesterone receptor, and the human epidermal growth factor receptor 2 (HER2). Although chemotherapy is the main form of treatment for patients with TNBC, the effectiveness of ...
Triple-negative breast cancers (TNBC) lack expression of oestrogen, progesterone and HER2 receptors. The gene expression profiles of TNBCs are similar t... MW Wong-Brown,CJ Meldrum,JE Carpenter,... - 《Breast Cancer Research & Treatment》 被引量: 64发表: 2015年 BRCA1/2 mutations and tripl...
In this type, all three molecular markers (ER, PR, and HER-2) are absent as suggested by the name triple-negative breast cancer. Approximately 12% of cases of breast cancer are triple-negative [37]. The triple-negative breast cancers are associated with BRCA1 gene mutation and...
Have what your doctor will call aBRCA mutation(a change in a gene), especially the gene BRCA1 Are inactive and have obesity after menopause Diagnosing Triple-Negative Breast Cancer There's no way to know which type of breast cancer you have until you’re tested by a doctor.Usually, triple...
Triple-negative breast cancers are often characterized by defects in DNA repair mechanisms involving homologous recombination; for example, owing to dysfunction of the breast cancer type 1 suscepti- bility protein (BRCA1). Indeed, mutations in BRCA1 are known to predispose individuals to hereditary ...
[translate] atake care of it. 作为关心它。 [translate] aRelative contributions of BRCA1 and BRCA2 mutations to "triple-negative" breast cancer in Ashkenazi Women. BRCA1和BRCA2变化的相对贡献对“三倍消极”乳腺癌在Ashkenazi妇女。 [translate] ...
Capivasertib's safety profile in the CAPItello-290 trial was comparable with prior reports of the agent in advanced triple-negative breast cancer. Questions Remain Around Neoadjuvant Chemoimmunotherapy in TNBC By Kristie L. Kahl April 23rd 2024 Survival Outcomes Improve With TIL Presence in TNBC By...
Fig. 1: Intrinsic molecular subtypes of breast cancer. Within each clinical subtype there are multiple molecular subtypes. ER endocrine receptor; TNBC triple negative breast cancer; HER2 Human Epidermal Growth Factor Receptor 2. Full size image ...