At least 10% of premenopausal triple negative breast cancer patients have BRCA1 mutations. Several researchers have suggested that all women under 50 with triple negative disease should be tested, even in the absence of a family history. However, many women without familial breast cancer would not...
Differential Claudin 3 and EGFR Expression Predicts BRCA1 Mutation in Triple-Negative Breast Cancerdoi:10.1080/07357907.2018.1499934Sabine DanzingerYen Yen TanMargaretha RudasMarie-Theres KastnerSigrid WeingartshoferDaniela MuhrChristian F. SingerkConFab Investigators...
a2-Hydroxychalcone and xanthohumol inhibit invasion of triple negative breast cancer cells. 2-Hydroxychalcone和xanthohumol禁止三倍消极乳腺癌细胞入侵。[translate] aTriple-negative breast cancer: BRCAness and concordance of clinical features with BRCA1-mutation carriers. 三倍消极乳腺癌: 临床特点BRCAness和...
Comprehensive study for BRCA1 and BRCA2 entire coding regions in breast cancer[J]. Clin Transl Oncol, 2021, 23(1): 74-81. doi: 10.1007/s12094-020-02385-9 [41] Staaf J, Glodzik D, Bosch A, et al. Whole-genome sequencing of triple-negative breast cancers in a population-based ...
BRCA1 deficient mouse models to study pathogenesis and therapy of triple negative breast cancer. Genetically engineered mice along with allograft and xenograft models can be used to effectively model triple negative breast cancer both for studies of pa... Eng-Wong,Jennifer,Zujewski,... - 《...
Zhao, MD; Si Yang, MD; Jingjing Hu, MD; Bajin We, MD; Ying Wu, PhD; Dai Zhang, MD; Huafeng Kang, MD; Zhijun Dai, PhD JAMA Network Open Original Investigation Constitutional BRCA1 Methylation and Risk of Incident Triple-Negative Breast Cancer and High-grade Serous Ovarian Cancer Per E...
Triple-negative breast cancer (TNBC), a subgroup that lacks expression of hormone receptors and HER2, overlaps with basal-like breast cancer (BLBC), a subgroup that expresses cytokeratins and other non-luminal (basal) genes Breast cancers occurring in patients with germline BRCA1 mutations are oft...
[translate] aPrognostic role of BRCA1 mutation in patients with triple-negative breast cancer. BRCA1 变化的预兆的作用在有三倍消极的乳腺癌的病人中。[translate]
Despite objective responses to poly(ADP-ribose) polymerase (PARP) inhibition and improvements in progression-free survival (PFS) compared to standard chemotherapy in patients with BRCA-associated triple-negative breast cancer (TNBC), benefits are transitory. Using high-dimensional single-cell profiling of...
[translate] aAssociation of BRCA1 germline mutations in young onset triple-negative breast cancer (TNBC). 在年轻的开始中的 BRCA1 germline 变化的协会三倍消极的乳腺癌 (TNBC)。[translate]