M2型:CellXVivo Human M2 Macrophage Differentiation Kit cat.no CDK013 三、MDSCs(髓系来源的免疫抑制细胞) 1、MDSCs来源及分类 MDSCs(髓系来源的免疫抑制细胞)是病变的中性粒细胞和单核细胞,在病理条件下,未成熟的髓系细胞被扩张并转化为免疫抑制的MDSC,具有较强的免疫抑制能力。MDSCs与许多病理条件下的免疫...
Recently, the expression of NLRP3 in CD4 + T cells, as well as in myeloid cells, has been described; however, a role of T cell鈥搃ntrinsic NLRP3 in Treg differentiation remains unknown. Here, we report that NLRP3 impeded the expression of Foxp3 independent of inflammasome activation in ...
如何做好文献综述(3):调节性T细胞介导免疫逃逸的作用 调节性 T 细胞(regulatory T cells, Treg)是一群具有免疫抑制功能的 T 细胞,主要分为天然型 Treg(CD4+CD25+Treg)和诱导型 Treg(iTreg)两大类。调节性T细胞也可分为 CD4+Treg及 CD8+Treg 两大类。其中,CD8+Treg 包括许多亚类:CD8+CD122+Treg,CD8+CD2...
调节性T细胞(Treg)是维持机体免疫平衡的主要的免疫抑制性细胞群,Treg细胞功能障碍在自身免疫性疾病病理生理学中发挥的作用程度仍然未知。2024年2月,Tomokazu S. Sumida等人在《Nature reviews》杂志上发表了一篇题为《The regulation and differ...
Regulatory T-cells (Tregs) are central in the maintenance of homeostasis and resolution of inflammation. However, the mechanisms that govern their differentiation and function are not completely understood. Herein, we demonstrate a central role for the lipid mediator biosynthetic enzyme 15-lipoxygenase ...
Protein Kinase C-θ (PKC-θ) has been shown to be a critical T cell receptor (TCR) signaling molecule that promotes the activation and differentiation of nave T cells into inflammatory effector T cells. We demonstrate here that PKC-θ-mediated signals inhibit iTreg differentiation via an AKT-...
2月15日,中国科学院科学家团队——微生物研究所张福萍研究团队在《美国国家科学院院刊》(PNAS)在线发表了题为E-protein regulatory network links TCR signaling to effector Treg cell differentiation的最新研究成果。该工作揭示了E蛋白介导了TCR信号对效应性Treg细胞分化的调控,并阐明了E蛋白调控效应性Treg细胞分化的...
Autoimmune diabetes in the Non Obese Diabetic (NOD) mouse model results from a breakdown of T cell tolerance caused by impaired tolerogenic dendritic cells development and regulatory T cells (Tregs) differentiation. Re-establishment of the Tregs pool has been shown to confer T cell tolerance and ...
Sumida TS et al. The regulation and differentiation of regulatory T cells and their dysfunction in autoimmune diseases. Nat Rev Immunol. 2024 Feb 19. Vahl JC et al. Continuous T cell receptor signals maintain a functional regulatory T cell pool. Immunity. 2014 Nov 20;41(5):722-36. ...
(5hmC), which is an intermediate of DNA demethylation30,31. The Tet genes are critical for the differentiation of CD4+T cells in mice32and humans33, as well as Treg homeostasis and function34,35,36. Despite these insights, the molecular mechanisms that can regulate Tet gene expression in ...