Human FOXP3+regulatory T (Treg) cells are central to immune tolerance. However, their heterogeneity and differentiation remain incompletely understood. Here we use single-cell RNA and T cell receptor sequencing to resolve Tregcells from healthy individuals and patients with or without acute graft-vers...
Protein kinase C-θ inhibits inducible regulatory T cell differentiation via an AKT-Foxo1/3a-dependent pathway. In this study, we demonstrate that PKC-θ-mediated signals inhibit inducible regulatory T cell (iTreg) differentiation via an AKT-Foxo1/3A pathway. TGF-... Jian,Ma,Yan,... - 《Jo...
This paper reviews the intervention effects of traditional Chinese medicine(TCM)monomers on the common ADs by regulating Th17/Treg differentiation balance based on intestinal flora:ulcerative colitis,rheumatoid arthritis and diabetes mellitus type 1. It is found that its mechanism of action may be to ...
原文信息 ▼ Short-chain fatty acids regulate B cells differentiation via FFAR2 to alleviate rheumatoid arthritis 2022-04-07, doi: 10.1111/bph.15852 灭活Akk菌可缓解牙龈卟啉单胞菌诱导的牙周炎 Journal of Clinical Periodontology——[8.728] ① 在瘦小鼠及肥胖小鼠中,诱导牙龈卟啉单胞菌相关牙周炎;② 3...
Migration of activated regulatory T (Treg) cells to inflamed tissue is crucial for their immune-modulatory function. While metabolic reprogramming during Treg cell differentiation has been extensively studied, the bioenergetics of Treg cell trafficking remains undefined. We have investigated the metabolic ...
Short-chain fatty acids regulate B cells differentiation via FFAR2 to alleviate rheumatoid arthritis 2022-04-07, doi: 10.1111/bph.15852 灭活Akk菌可缓解牙龈卟啉单胞菌诱导的牙周炎 Journal of Clinical Periodontology——[8.728] 在瘦小鼠及肥胖小鼠中,诱导牙龈卟啉单胞菌相关牙周炎; 3周后口服或灌胃活Akk...
In the absence of a second signal from a proinflammatory cytokine, FOXP3 can inhibit RORγt function and drive Treg differentiation. However, when the cell also receives a signal from a proinflammation cytokine (e.g., IL-6), FOXP3 function is inhibited and the Th17 differentiation pathway ...
Short-chain fatty acids regulate B cells differentiation via FFAR2 to alleviate rheumatoid arthritis 04-07, doi: 10.1111/bph.15852 【主编评语】浙江大学医学院郑彩虹、Ye Yiqing与团队的研究成果。短链脂肪酸(SCFAs)是肠道菌群的主要代谢产物之一,且与宿主的炎症和免疫反应密切相关。本文主要探究SCFAs对类风湿性...
(1): 15-28.5. Stockis J, Roychoudhuri R, Halim TYF. Regulation of regulatory T cells in cancer. Immunology 2019; 157(3): 219-31.6. Plitas G, Rudensky AY. Regulatory T Cells: Differentiation and Function. Cancer immunology research 2016; 4(9): 721-5.7. Namdar A, Mirzaei R, Memarne...
Regulatory T-cells (Tregs) are central in the maintenance of homeostasis and resolution of inflammation. However, the mechanisms that govern their differentiation and function are not completely understood. Herein, we demonstrate a central role for the lipid mediator biosynthetic enzyme 15-lipoxygenase ...