Immunology Signaling pathway cross-talk upstream of regulatory T cell differentiation UNIVERSITY OF MASSACHUSETTS AMHERST Barbara A. Osborne SamonJeremy BNotch and its ligands have been implicated in the regulation and differentiation of various CD4T-helper cells. By directly inducing the expression of ...
CD8+ T cells specific for cancer cells are detected within tumours. However, despite their presence, tumours progress. The clinical success of immune checkpoint blockade and adoptive T cell therapy demonstrates the potential of CD8+ T cells to mediate an
The importance of major hubs of metabolic regulation (mTOR, and AMPK) in activation and T helper cell differentiation will also be explored. Finally, as a prominent example of how metabolism can be therapeutically exploited, we describe the impact of fatty acid metabolism on T cell differentiation...
Epigenetic modifying proteins can act differentially within CD8+ T cell differentiation subsets to regulate gene expression, and altering the activities of these enzymes can have profound effects on T cell differentiation and function. T cell exhaustion represents a state of arrested differentiation. Rever...
Figure 5: Integrated single-cell RNA and chromatin accessibility profiling predict enhancer-gene interactions of human tumor infiltrating T cells 5. CRISPRi/a干扰技术验证不同状态T细胞功能特异性基因的增强子元件 超级增强子在决定细胞类型特异性基因的表达调控中发挥着重要作用,他们通常是一连串增强子元件的集合,...
Keywords tumor immunity adoptive T cell therapy CD8+ T cell differentiation PD-L1/PD-1 Research topic(s) CP: Immunology CP: Cancer Sorry, something went wrong. Please try again and make sure cookies are enabledReferences 1 M.F. Sanmamed, L. Chen A Paradigm Shift in Cancer Immunotherapy: ...
在这里,我们展示了含有 Long Interspersed Nuclear Element 1(LINE1,长散布核元件1)的非典型剪接变体促进或强制 Naive CD4+ T cell的静止状态。在Naive CD4+ T细胞中,含有LINE1的转录本由转录因子IRF4调节,并被核仁蛋白将其维持在染色质上;这些转录本作为顺式元件,阻碍组蛋白3赖氨酸36三甲基化(H3K36me3)的...
THERAPEUTIC AND DIAGNOSTIC METHODS USING SOLUBLE T CELL SURFACE MOLECULES measurement of soluble receptors of t cell growth factor, soluble antigens of t cell differentiation and soluble molecules or fragments of molecules on and use of these measures in the diagnosis and therapy of diseases and trou...
New differentiation pathway for double-negative regulatory T cells that regulates the magnitude of immune responses. Blood 2007; 109: 4071–4079. 12. Tiegs G, Hentschel J, Wendel A. A T cell-dependent experimental liver injury in mice inducible by concanavalin A. J Clin Invest 1992; 90: 196...
Using single-cell RNA sequencing, we show that iNKT, MAIT and γδ T cells mature via shared, branched differentiation rather than linear maturation or TCR-mediated instruction. Simultaneous TCR clonotyping analysis reveals that thymic maturation of all three types is accompanied by clonal selection...