Immunology Signaling pathway cross-talk upstream of regulatory T cell differentiation UNIVERSITY OF MASSACHUSETTS AMHERST Barbara A. Osborne SamonJeremy BNotch and its ligands have been implicated in the regulation and differentiation of various CD4T-helper cells. By directly inducing the expression of ...
D. Obstacles posed by the tumor microenvironment to T cell activity: a case for synergistic therapies. Cancer Cell 31, 311–325 (2017). CAS PubMed PubMed Central Google Scholar Henning, A. N., Roychoudhuri, R. & Restifo, N. P. Epigenetic control of CD8+ T cell differentiation. Nat...
ATF3 promoted TH1 cell differentiation by inducing the expression of Stat1, a key regulator of TH1 cell differentiation. After viral infection, an interaction between CGRP produced by neurons and RAMP3 expressed on T cells enhanced the anti-viral IFNγ-producing TH1 and CD8+ T cell response, ...
Correspondingly, single-cell transcriptomic analysis uncovered high levels of Blimp-1 expression in cytotoxic CD4+ T cells, transcriptionally separating them from other Th cell subsets, such as Tfh cells and Th1 cells [25]. Other TFs contributing to the regulation of CD4 CTL differentiation are ...
The importance of major hubs of metabolic regulation (mTOR, and AMPK) in activation and T helper cell differentiation will also be explored. Finally, as a prominent example of how metabolism can be therapeutically exploited, we describe the impact of fatty acid metabolism on T cell differentiation...
The Wnt pathway has a central role in stem cell regulation. Gattinoni et al. now show that activation of the Wnt signaling cascade in naive CD8+ T cells blocks their differentiation into effector T cells and triggers instead a memory stem cell–like phen
【and the absence of tumor-specific T-cell recognition and cytotoxicity .】在 B2M 基因敲除小鼠肺癌模型中观察到了相同的【Identical完全相同的】结果,该模型显示出对 PD-1 阻断的抗药性。此外,溶酶体途径【lysosomal pathway】与 CD8+ T 淋巴细胞浸润减...
et al. The long intergenic noncoding RNA landscape of human lymphocytes highlights the regulation of T cell differentiation by linc-MAF-4.Nat. Immunol.16, 318–325 (2015). (1)补充信息含LINE1转录本的表达定量 我们使用Salmon 1.1.0评估了含有LINE1的转录本的表达(使用默认参数进行比对)以便最大限度...
Chestnut Studying 摘要 The efficacy of chimeric antigen receptor (CAR) T cell therapy is hampered by relapse in hematologic malignancies and by hyporesponsiveness in solid tumors. Long-lived memory …
Epigenetic modifying proteins can act differentially within CD8+ T cell differentiation subsets to regulate gene expression, and altering the activities of these enzymes can have profound effects on T cell differentiation and function. T cell exhaustion represents a state of arrested differentiation. Rever...