Moreover, a functional single nucleotide polymorphism at codon 72 of TP53 gene was found to be associated with earlier onset of sporadic glioblastomas, opening new insights into the role of low-risk variants as genetic susceptibility to develop brain tumors. This chapter reviews the genetic ...
In this review, we will shatter the classical and traditional image of tumor protein p53 (TP53) as a tumor suppressor gene by emphasizing its multiple oncogenic properties that make it a potential therapeutic target that should not be underestimated. Analysis of the data generated by the various ...
The standard classification used to define the various cancer genes confines tumor protein p53 (TP53) to the role of a tumor suppressor gene. However, it is now an indisputable fact that many p53 mutants act as oncogenic proteins. This statement is based on multiple arguments including the mutat...
Schiffman, MD JAMA Comment & Response TP53 Gene and Cancer Resistance in Elephants Claudio Casola, PhD JAMA Comment & Response TP53 Gene and Cancer Resistance in Elephants Raymond P. Perez, MD; Takefumi Komiya, MD, PhD JAMA Comment & Response TP53 Gene and Cancer Resistance in Elephants Allan...
The standard classification used to define the various cancer genes confines tumor protein p53 (TP53) to the role of a tumor suppressor gene. However, it is now an indisputable fact that many p53 mutants act as oncogenic proteins. This statement is based on multiple arguments including the mutat...
ObjectiveTo investigate the clinical characteristics of children with brain tumors complicated with Li-Fraumeni syndrome (LFS) and analyze its association with TP53 gene mutation. MethodsRetrospective analysis was conducted on clinical data of pediatric patients diagnosed with LFS at the outpatient clinic ...
ObjectiveTo investigate the clinical characteristics of children with brain tumors complicated with Li-Fraumeni syndrome (LFS) and analyze its association with TP53 gene mutation. MethodsRetrospective analysis was conducted on clinical...
Gene Name TP53 Accession No. P04637 Alternate Names Antigen NY-CO-13; BCC7; Cellular tumor antigen p53; FLJ92943; LFS1; Mutant tumor protein 53; p53; p53 tumor suppressor; P53_HUMAN; Phosphoprotein p53; Tp53; Transformation related protein 53; TRP53; Tumor protein 53; Tumor protein p53;...
TP53, a well-known tumour suppressor gene that encodes p53, is frequently inactivated by mutation or deletion in most human tumours. A tremendous effort has been made to restore p53 activity in cancer therapies. However, no effective p53-based therapy has been successfully translated into clinical...
Immunogen DescriptionSynthetic peptide corresponding to residues near the N terminal of human tumor protein p53 regulated apoptosis inducing protein 1 Target NameTP53AIP1 Alternative NamesP53AIP1 Accession No.Swiss-Prot#: Q9HCN2 NCBI Gene ID: 63970 ...