Topoisomerases are enzymes that modify and regulate the topological state of DNA. These enzymes participate in many cellular metabolic processes, which are associated with separation of complementary DNA strands such as replication, transcription, recombination and repair. Topoisomerases are classified into...
Topoisomerase I is preferentially associated with normal SV40 replicative intermediates, but is associated with both replicating and nonreplicating SV40 DNAs which are deficient in histones 喜欢 0 阅读量: 6 作者:Champoux,James,J.DOI: 10.1093/nar/20.13.3347 被引量: 30 ...
Topoisomerases are enzymes that interconvert different topological states of DNA, such as levels of supercoiling, catenanes (links) and knots. They are vital to all DNA-related processes and are the targets for a number of antibacterial and anticancer agents. Keywords: DNA topology; gyrase; repli...
Krawczyk, C., Dion, V., Schar, P. & Fritsch, O. Reversible Top1 cleavage complexes are stabilized strand-specifically at the ribosomal replication fork barrier and contribute to ribosomal DNA stability.Nucleic Acids Res.42, 4985–4995 (2014). ArticleCASPubMedPubMed CentralGoogle Scholar Hohmann...
In promoters where multiple GC boxes are present, it is common for each GC box to have a different function according to its position with respect to the transcription start point and other flanking elements. Within the human topoisomerase IIα promoter, GC1 is contained in the minimal promoter...
We show that centromeres are unique in that they are associated with high levels of Top3, but low levels of Top1 and Top2, suggesting that Top3 is particularly important for centromeric DNA topology. Impaired function of Top3 or its partner Rqh1 results in chromosome segregation defects and...
Type IIA topoisomerase (TOP2A) is upregulated in hepatocellular carcinoma (HCC) and its expression is positively correlated with poor prognosis. However, the underlying molecular mechanism of this connection are poorly understood. Hence, the present work aimed to examine the possible mechanisms which ma...
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The mechanisms and molecular determinants of tumour response to TOP1 inhibitors are reviewed, and rational combinations of TOP1 inhibitors with other drugs are considered based on current knowledge of repair and checkpoint pathways that are associated with TOP1-mediated DNA damage. 展开 ...
DL is sometimes associated with X-linked Alport syndrome (AS), an inherited nephropathy caused by COL4A5 gene mutations. COL4A5 is tightly linked, in a head-to-head fashion, to the functionally related and coordinately regulated COL4A6 gene. No X-linked AS cases are due to COL4A6 ...