We have recently shown that the topoisomerase II inhibitor, etoposide (VP16), could trigger caspase-2 pre-mRNA splicing in human leukemic cell lines. This leads to increased inclusion of exon 9, which is specifically inserted into the short caspase-2S isoform mRNA and absent from the long casp...
TOPO-1CES-2colorectal canceririnotecanchemotherapyPFSOSTopoisomerase 1 (TOPO-1) and carboxylesterase 2 (CES-2) are found to play crucial roles in the pathogenesis of various cancers. The prognostic role of TOPO-1 and CES-2 in patients with metastatic colorectal cancer (mCRC) who underwent ...
Predictive role of midtreatment changes in survivin, GSTP1, and topoisomerase 2α expressions for pathologic complete response to neoadjuvant chemotherapy ... Introduction: The primary aim of this study is to investigate the effect of change in the expression levels of survivin, glutathione-S-transfe...
The extent to which the DNA relaxation activities of eukaryotic topoisomerases (topo I and topo II) are redundant during gene transcription is unclear. Although both enzymes can often substitute for each other in vivo, studies in vitro had revealed that the DNA cross-inversion mechanism of topo ...
Functionally, the HMGB2-TOP1cc-cGAS axis determines the response of orthotopically transplanted ex vivo therapy-induced senescent cells to immune checkpoint blockade in vivo. Together, these findings establish a HMGB2-TOP1cc-cGAS axis that enables cytoplasmic chromatin recognition and response to ...
The topoisomerase enzymes are essential for DNA metabolism, where they act to adjust the number of supercoils in DNA, a key requirement in the cellular processes of transcription and replication. Their enzymatic mechanism creates transient nicks (type I) or breaks (type II) in the double stranded...
化合物 TOPOISOMERASE I INHIBITOR 2 CAS号: 2588211-44-1 英文名: 6H-[1]Benzopyrano[3,4-b]quinoline, 9,10-dimethoxy- 英文别名: Topoisomerase I inhibitor 2;6H-[1]Benzopyrano[3,4-b]quinoline, 9,10-dimethoxy- 中文名: 化合物 TOPOISOMERASE I INHIBITOR 2 ...
The vast majority of the cases tested positive for HPV16 (84%); 1 case tested positive for both HPV16 and HPV18. Positive HPV16 status was more frequent in early stages than in advanced stages (P=0.008). Positive immunohistochemical reactivity for MCM2 and TOP2A protein was observed in 71.6 ...
Liu, Design of Topoisomerase Inhibitors to Overcome MDR1-Mediated Drug Resistance. Appendices: J.C. Wang, An Introduction to DNA Supercoiling and DNA ... Leroy F. Liu 被引量: 18发表: 1994年 In vitro antifungal activity of DNA topoisomerase inhibitors. The data of this study indicate that ...
DNA topoisomerase 2 binding protein 1 antibody Basic information More.. Product Name: DNA topoisomerase 2 binding protein 1 antibody Synonyms: CAS: MF: MW: 0 EINECS: Mol File: Mol File Information Error Report Your Email: Browse by Nationality DNA topoisomerase 2 binding protein 1 antibody...