Enzyme activity for both topoisomerase I and topoisomerase II was detected in both pachytene spermatocytes and in round spermatids; topoisomerase II exhibited a higher level of activity in meiotic spermatocytes than in round spermatids. In cultured cells, camptothecin, an inhibitor of topoisomerase I...
The absence of DNA topoisomerase I leads to a temporary delay in the extension of the short DNA chains; this delay in chain elongation is also reflected in the rate of total DNA synthesis in the Δ top1 mutant during the early S-phase. Thus, in wild-type cells. DNA topoisomerase I is...
Eukaryotic topoisomerase I is an essential enzyme that regulates the changes in DNA topology, relaxing the superhelical tension associated with DNA replication, transcription and recombination. Human topoisomerase I is of significant medical interest being the only target of the antitumor drug camptothecin...
What is the role of enzymes in DNA replication? What is role of topoisomerases in DNA supercoiling? What does DNA ligase do? What is the function of dideoxynucleotides in Sanger DNA sequencing? What does DNA stand for? What is the role of proteins in a chromosome?
Before the physiological functions of topoisomerase II can be effectively dissected or its drug interactions fully exploited, it is imperative to understand the mechanism by which this important enzyme arries out its catalytic cycle. 展开 DOI: 10.1002/bies.950130603 被引量: 544 ...
Type II topoisomerases are essential ATP-dependent homodimeric enzymes required for transcription, replication, and chromosome segregation. These proteins alter DNA topology by generating transient enzyme-linked double-strand breaks for passage of one DNA strand through another. The central role of type ...
classes of SUMO proteases. SUMO proteases are now known to fall into one of three distinct classes: the well-characterized UBL-specific protease (Ulp) and sentrin-specific protease (SENP) class; the desumoylating isopeptidase (DESI) class; or the ubiquitin-specific protease-like 1 (USPL1) ...
However, the stimulation of ATR kinase activity by binding of topoisomerase binding protein 1 (TopBP1) to ATRIP-ATR can occur independently of the interaction of ATRIP with RPA. Our results support the idea of a multistep model for ATR activation that requires separable localization and ...
Ventricular Fibrillation in a Globally Ischemic Heart: From Cell to ECG Regulation and Function of the p14ARF/topoisomerase I Complex in Cancer HIV Treatment Adherence for Persons with Low-Literacy Subendothelial Binding of Von Willebrand FactorRecently...
Topoisomerase IIbeta negatively modulates retinoic acid receptor alpha function: a novel mechanism of retinoic acid resistance. Mol Cell Biol. 2008;28(6):... McNamara S,Wang HL,Hanna N,... - 《Molecular & Cellular Biology》 被引量: 0发表: 2008年 Topoisomerase II beta negatively modulates ret...