Osheroff N, Zechiedrich EL, Gale KC (1991) Catalytic function of DNA topoisomerase II. Bioessays 13:269–273Osheroff N, Zechiedrich EL, Gale KC (1991) Catalytic function of DNA topoisome...
Moreover, topoisomerase II also has been identified as the primary cellular target for several widely used antineoplastic drugs. Before the physiological functions of topoisomerase II can be effectively dissected or its drug interactions fully exploited, it is imperative to understand the mechanism by ...
m-AMSA-resistant HL-60 cells have higher protein-DNA complex formation than m-AMSA-sensitive HL-60 cells, suggesting different activities of topoisomerase II in drug-resistant vs. drug-sensitive cells. 展开 关键词: DNA-topoisomerase \{II\} complex HL-60 cell m-AMSA Dimethylsulfoxide Retinoic ...
Type II topoisomerases are essential ATP-dependent homodimeric enzymes required for transcription, replication, and chromosome segregation. These proteins alter DNA topology by generating transient enzyme-linked double-strand breaks for passage of one DNA strand through another. The central role of type ...
Topoisomerase II beta negatively modulates retinoic acid receptor alpha function: a novel mechanism of retinoic acid resistance Topoisomerase IIbeta negatively modulates retinoic acid receptor alpha function: a novel mechanism of retinoic acid resistance. Mol Cell Biol. 2008;28(6):... McNamara S,Wang...
What is the role of enzymes in DNA replication? What is role of topoisomerases in DNA supercoiling? What does DNA ligase do? What is the function of dideoxynucleotides in Sanger DNA sequencing? What does DNA stand for? What is the role of proteins in a chromosome?
Since this could reflect the loss of interaction with an important ligand, we have examined whether the C-terminal domain of the yeast enzyme mediates interaction with the regulatory β subunit of PK CK2, which was previously reported to bind topoisomerase II. We find that point mutation of the...
Small ubiquitin-related modifier (SUMO) proteases control cellular mechanisms, including transcription, cell division and ribosome biogenesis. The function of SUMO proteases is to remove SUMO from SUMO-modified proteins and (for some SUMO proteases) to process precursor SUMO, which is required for the...
Eukaryotic topoisomerase I is an essential enzyme that regulates the changes in DNA topology, relaxing the superhelical tension associated with DNA replication, transcription and recombination. Human topoisomerase I is of significant medical interest being the only target of the antitumor drug camptothecin...
P25 26 WP – GENETIC ANALYSIS OF TOPOISOMERASE I FUNCTION IN YEASTmotion analysiscerebral palsyswimmingtrunkdoi:10.1016/B978-0-12-168561-4.51123-9MICHAEL CHRISTMANF. SCOTT KIEFFFRED DIETRICHGERALD R. FINKRadiation Research: A Twentieth-century Perspective...