DNA topoisomerase I is involved in both repression and activation of transcription. Nature 1993; 365:227 - 32.Merino, A.; Madden, K.R.; Lane, W.S.; Champoux, J.J.; Reinberg, D., DNA topoisomerase I is involved in both repression and activation of transcription, Nature, 1993, 365, ...
摘要: TopoisomeraseII beta Is Involved in Initiation of Interstrand Cross-Link Repair in Mammals 会议名称: 45th Annual Meeting of the 会议时间: 2014 收藏 引用 批量引用 报错 分享 全部来源 求助全文 ResearchGate eprint.ncl.ac.uk 相似文献Regulation of DNA cross-link repair by the Fanconi anemia/...
Apoptotic execution is characterized by dramatic changes in nuclear structure accompanied by cleavage of nuclear proteins by caspases (reviewed in [1]). Cell-free extracts have proved useful for the identification and functional characterization of activities involved in apoptotic execution [2–4] and ...
In addition to its classical DNA nick-ing-closing activities which are needed for relaxation of supercoiled DNA, topoisomerase I can phosphorylate certain splicing factors. The enzyme is also involved in transcriptional regulation through its ability to associate with other proteins in the TFIID-, and...
Prognostic role of topoisomerase-IIalpha in advanced ovarian cancer patients. To our knowledge, very few data about the role of Topoisomerase IIalpha (TOPO-IIalpha), an enzyme involved in critical steps of tumour cell proliferation a... Ferrandina,Petrillo,Carbone,... - 《British Journal of ...
brucei and the first 384 amino acids in L. donovani (Sengupta et al., 2005a,b). ATP binding to the nucleotide-binding cassette promotes the dimerization of the N-terminal ATPase domains, which control the open/close movements of the protein that are involved in DNA releasing (Wei et al....
One suggestion involved localization of TopoIV at the terminus and activity carried out only in the D-period (after all replication is completed)10. Other studies indicated localization of TopoIV in clusters at oriC, where a key interaction with MukB was required for both localization and ...
DNA topoisomerase II (topo II) is the target for a number of antineoplastic agents. Down-regulation of this enzyme is one form of drug resistance. Topo II is also involved in DNA replication and transcription and serves as an indicator of proliferation rate in many human malignancies. This stu...
The nuclear factor kappaB (NF-kappaB) is involved in T cell activation and enhances HIV-1 gene expression. It is activated in response to numerous stimuli, including oxidative stress. Oxidative stress damages membrane lipids, proteins and nucleic acids. We have shown previously that oxidative DNA ...
Merino A, Madden K, Lane WS, Champoux J, Reinberg D: DNA topoisomerase I is involved in both repression and activation of transcription. Nature. 1993, 365: 227-232. 10.1038/365227a0. Article CAS PubMed Google Scholar Gobert C, Skladanowski A, Larsen AK: The interaction between p53 and...