Topoisomerases are unique enzymes that regulate torsional stress in DNA to enable essential genome functions, including DNA replication and transcription. Although all cells in an organism require topoisomerases to maintain normal function, the nervous system in particular shows a vital need for these ...
Through these breaks at several points, topoisomerase helps in untangling the DNA, which resealed later utilizing ATP. The main function of topoisomerases is unlinking the DNA by making several transient cuts inside through a conserved tyrosine amino acid residue at the catalytic position of the ...
Eukaryotic topoisomerase I is an essential enzyme that regulates the changes in DNA topology, relaxing the superhelical tension associated with DNA replication, transcription and recombination. Human topoisomerase I is of significant medical interest being the only target of the antitumor drug camptothecin...
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function, in addition to suppressing fibroblast proliferation. Indeed, inhibiting TGF-β signaling has been proposed as a therapy targeting the remodeling phase of wound healing11,12. TGF-β is proteolytically activated by MMPs and facilitates extracellular matrix remodeling after surgery29,30. Thus, ...
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(CTR1) has been recently shown to transport platinum drugs, emphasizing the crucial function of CTR1 in platinum-drug sensitivity in cancer chemotherapy [327,328]. A promising phase I clinical trial using cotreatment of trientine (a copper chelator) and carboplatin has shown CTR1-mediated higher...
Kinase independent functions have been mainly described for the ERBB family, but may be more widespread in RTK signaling. This is not surprising given that the function of RTKs relies heavily on their abilities to assemble multi-protein signaling complexes. Although the focus has been on proteins...
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Moreover, given the function of UCHL3 in upre- gulating HR, which is critical for maintaining genome integrity in normal somatic and stem cells, identifying the activators of UCHL3 could potentially improve the efficiency of cellular reprogramming and the quality of reprogrammed cells. In our ...