Eukaryotic topoisomerase I is an essential enzyme that regulates the changes in DNA topology, relaxing the superhelical tension associated with DNA replication, transcription and recombination. Human topoisomerase I is of significant medical interest being the only target of the antitumor drug camptothecin...
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function, in addition to suppressing fibroblast proliferation. Indeed, inhibiting TGF-β signaling has been proposed as a therapy targeting the remodeling phase of wound healing11,12. TGF-β is proteolytically activated by MMPs and facilitates extracellular matrix remodeling after surgery29,30. Thus, s...
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andXanthomonadaceaeto CAZy enzymes were higher in later days, likely resulting from age and the increased intake of a solid diet. Moreover, these three bacterial families were the main ARG hosts from d42 to d84, reflecting that the function of the rumen microbiome is associated with the re...
To examine which domain of FAM35A is required for its function in NHEJ, we carried out complementation experiments. Wild-type FAM35A, but not AA (P14A/P17A, which loses its interaction with REV7) and ΔOB23 (1–576 aa, which loses interaction with C20ORF196 and ssDNA), restored the...
1.Topographic study of a given place, especially the history of a region as indicated by its topography. 2.MedicineThe anatomical structure of a specific area or part of the body. 3.Mathematics a.The study of certain properties that do not change as geometric figures or spaces undergo continu...
infinite,space- the unlimited expanse in which everything is located; "they tested his ability to locate objects in space"; "the boundless regions of the infinite" math,mathematics,maths- a science (or group of related sciences) dealing with the logic of quantity and shape and arrangement ...
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Moreover, given the function of UCHL3 in upre- gulating HR, which is critical for maintaining genome integrity in normal somatic and stem cells, identifying the activators of UCHL3 could potentially improve the efficiency of cellular reprogramming and the quality of reprogrammed cells. In our ...