The role of topoisomerase II伪 and 尾 in drug resistanceHochhauserDanielHarrisAdrian L
DNA topoisomerase I (Top1) is converted into a cellular poison by camptothecin (CPT) and various endogenous and exogenous DNA lesions. In this study, we us... I Plo,ZY Liao,JM Barceló,... - 《Dna Repair》 被引量: 588发表: 2003年 DNA damage-triggered apoptosis: critical role of DNA...
topoisomerase (redirected fromTopoisomerases) Medical Encyclopedia to·po·i·som·er·ase (tō′pō-ī-sŏm′ə-rās′, -rāz′) n. Either of two isomerase enzymes that alter the topology of DNA molecules by breaking and reconnecting coiled strands. ...
DNA topoisomerase II (TOP2) is an enzyme that resolves DNA topological problems and plays critical roles in various nuclear processes. Recently, a heterozygous H58Y substitution in the ATPase domain of human TOP2B was identified from patients with autism
摘要: The ability of type II DNA topoisomerases to pass one DNA double helix through another can be explained by a mechanism involving two gates in the enzyme structure.关键词: FUCUS-VESICULOSUS FUCUS-SPIRALIS HYBRIDIZATION SCOTLAND DOI: 10.1016/S0960-9822(00)00227-X ...
More specifically, for therapeutic purpose, it is essential to target enzymes involved in viral replication as well as transcription. In addition, we need to target those catalytic sites involved in the key enzymatic reaction. In SARS-CoV-2, the main role of 3CLpro and PLpro proteases is to...
Camptothecin (CPT) binds reversibly to, and thereby stabilizes, the cleavable complex formed between DNA and topoisomerase I. The nature of the interaction... RP Hertzberg,RW Busby,MJ Caranfa,... - 《Journal of Biological Chemistry》 被引量: 134发表: 1990年 Role of the 20-Hydroxyl Group in...
The role of glycolytic metabolism in cancer cells and nearby tumor microenvironment is complex and diverse. For example, enhanced glycolysis in cancerous cells relies on LDH-mediated production of NAD+ from NADH, reducing NADH:NAD+ ratio and suppressing p53 function [5]. In murine TNBC models, ...
The human gut microbiome is a complex microbial community that is strongly linked to both host health and disease. However, the detailed molecular mechanisms underlying the effects of these microorganisms on host biology remain largely uncharacterized. The development of non-lethal, small-molecule inhibi...
It is presently unclear where the balance lies and how the fate of a tumour cell is eventually decided, although the part of the UPR pathway that upregulates endoplasmic reticulum chaperones seems to have a protective role during tumour development. In vitro activation of the UPR alters the ...