In recent years it has become more and more apparent that the regulation of gene expression by RNA-binding proteins (RBPs) is of utmost importance for most cellular signaling pathways. RBPs control several aspects of RNA biogenesis including splicing, localization, stability, and translation ...
MicroRNA (miRNA) biogenesis is finely controlled by complex layers of post-transcriptional regulators, including RNA-binding proteins (RBPs). Here, we show that an RBP, QKI5, activates the processing of primary miR-124-1 (pri-124-1) during erythropoiesis
G3BP RNA-binding proteins are important components of stress granules (SGs). Here, we analyze the role of the Drosophila G3BP Rasputin (RIN) in unstressed cells, where RIN is not SG associated. Immunoprecipitation followed by microarray analysis identifies over 550 mRNAs that copurify with RIN...
RNA-binding proteins (RBPs) are increasingly identified as post-transcriptional drivers of cancer progression. The RBP LARP1 is an mRNA stability regulator, and elevated expression of the protein in hepatocellular and lung cancers is correlated with adverse prognosis. LARP1 associates with an mRNA in...
The results of genetic studies in Arabidopsis indicate that three proteins, the RNase III DICER-Like1 (DCL1), the dsRNA-binding protein HYPONASTIC LEAVES1 (HYL1), and the C2H2 Zn-finger protein SERRATE (SE), are required for the accurate processing of microRNA (miRNA) precursors in the ...
The RNA-binding protein Fus directs translation of localized mrnas in APC-RNP granules 喜欢 0 阅读量: 35 作者: Yasuda,K.,Zhang,H.,Loiselle,D.,Haystead,T.,Macara,I.G.,Mili,S. 摘要: RNA localization pathways direct numerous mRNAs to ...
Regulation of Mdm2 mRNA Stability by RNA-binding Protein RNPC1 Oncotarget. 2013 Aug;4(8):1121-2. Z Jin,E Xu,X Chen - 《Oncotarget》 被引量: 8发表: 2013年 255 The RNA-binding Protein RNPC1 Regulates Mdm2 Expression Via mRNA Stability 255 The RNA-binding Protein RNPC1 Regulates Mdm2 ...
RNA-binding protein Nrd1 directs poly(A)-independent 3'-end formation of RNA polymerase II transcripts. The RNA-binding protein Nab3, the putative RNA helicase Sen1, and the intact C-terminal domain of pol II are also required for efficient response to ... EJ Steinmetz,NK Conrad,DA Brow...
Papadaki, O. et al. Control of thymic T cell maturation, deletion and egress by the RNA-binding protein HuR.J. Immunol.182, 6779–6788 (2009). Diaz-Munoz, M. D. et al. The RNA-binding protein HuR is essential for the B cell antibody response.16, 415–425 (2015). ...
AU-rich element (ARE)-mediated mRNA decay represents a key mechanism to avoid excessive production of inflammatory cytokines. Tristetraprolin (TTP, encoded by Zfp36) is a major ARE-binding protein, since Zfp36−/− mice develop a complex multiorgan i