Gene expression in higher eukaryotic cells orchestrates interactions between thousands of RNA-binding proteins (RBPs) and tens of thousands of RNAs1. The kinetics by which RBPs bind to and dissociate from their RNA sites are critical for the coordination of cellular RNA–protein interactions2. Howe...
& Reik, W. Dynamics of the epigenetic landscape during the maternal-to-zygotic transition. Nat. Rev. Mol. Cell Biol. 19, 436–450 (2018). CAS Google Scholar Hsu, H. T. et al. Recruitment of RNA polymerase II by the pioneer transcription factor PHA-4. Science 348, 1372–1376 (2015...
Embryonic stem cell (ESC) self-renewal and cell fate decisions are driven by a broad array of molecular signals. While transcriptional regulators have been extensively studied in human ESCs (hESCs), the extent to which RNA-binding proteins (RBPs) contribute to human pluripotency remains unclear. ...
RNA-seq INTRODUCTION The mammalian brain is a complex organ composed of highly specialized anatomical structures that control multiple physiological processes, such as memory, metabolism, energy homeostasis, motor skills, visuospatial processing, body temperature and behavior, among others. Although the rumi...
The landscape of circular RNA in cancer. Cell. 2019;176:869–881.e13. Article CAS PubMed PubMed Central Google Scholar Kristensen LS, Andersen MS, Stagsted LVW, Ebbesen KK, Hansen TB, Kjems J. The biogenesis, biology and characterization of circular RNAs. Nat Rev Genet. 2019;20:675...
Firstly, we observed that the enrichment of chromatin associated factors (CTCF and RAD21) at TAD boundaries increases with the TAD order (the innermost one is referred to as order of 1 in a hierarchy), suggesting a relationship between hierarchical TADs’ formation and the binding strength of ...
Prostate cancer represents one of the most pressing health concerns in oncology, accounting for a significant proportion of cancer-related morbidity and mortality among men globally [1].The advent of docetaxel-based chemotherapy has marked a paradigm shift in the therapeutic landscape, offering a survi...
2024年12月9日,Molecular Plant在线发表了中山大学生命科学学院陈月琴教授和广东省农业科学院农业生物基因研究中心于洋副研究员团队题为“The long noncoding RNA ALEX1 confers a functional phase state of ARF3 to enhance rice resistance to bacterial pathogens”的研究论文。该研究揭示长链非编码RNA ALEX1通过调控...
AUXIN RESPONSE FACTORS (ARFs) are plant-specific transcription factors (TFs) that couple perception of the hormone auxin to gene expression programs essential to all land plants. As with many large TF families, a key question is whether individual member
The landscape of circular RNA in. Cancer. Cell 176, 869–881.e813 (2019). CAS Google Scholar Cortes-Lopez, M. et al. Global accumulation of circRNAs during aging in Caenorhabditis elegans. BMC Genomics 19, 8 (2018). Article CAS PubMed PubMed Central Google Scholar Gruner, H., ...