RNA-binding proteins (RBPs) are critical effectors of gene expression, and as such their malfunction underlies the origin of many diseases. RBPs can recognize hundreds of transcripts and form extensive regulatory networks that help to maintain cell homeostasis. System-wide unbiased identification of ...
RNA-binding proteins (RBPs) are central to most if not all cellular processes, dictating the fate of virtually all RNA molecules in the cell. Starting with pioneering work on ribosomal proteins, studies of bacterial RBPs have paved the way for molecular studies of RNA–protein interactions. Wor...
The RNA Recognition Motif-containing protein family in particular is highly diversified within plants when compared to animals, with ∼50% of these proteins having no obvious ortholog in metazoans [50]. Interestingly, this specificity of plant RNA-binding proteins and their roles in various stress...
The Research Progress of Plant RNA Binding Proteins ZaiBao ZHANG1,2(),WanJie LI1,JiuLi LI1,Chi ZHANG1,MengHui HU1,Lin CHENG1,HongYu YUAN1,2 RichHTML 117 PDF 800 摘要/Abstract 摘要: 在真核生物中,RNA结合蛋白(RBPs)是一类重要的转录后调控因子,通过与RNA结合形成核糖核蛋白复合物来调节真核生...
Finding binding preferences of RNA binding proteins : Literature ReviewKazan, Hilal
Review|Open Access New insights into the interplay between long non-coding RNAs and RNA-binding proteins in cancer Zi-Ting Yao, Yan-Ming Yang, Miao-Miao Sun, Yan He, Long Liao, Kui-Sheng Chen, Bin Li Cancer Communications....
很大程度上,潜在的分子机制是由RNA转录本与大量RNA结合蛋白(RNA binding proteins, RBPs)在物理层面的互作介导的,这些蛋白调节RNA剪接(splicing)、稳定性(stability)、核转运(nuclear export)和翻译(translation)等特性。因此,阐释这些RBPs的RNA结合...
RBPs are proteins ubiquitously expressed across human tissues that recognize specific binding sequences and/or a secondary structures of RNA molecules controlling RNA metabolism either at the nuclear (transcription, splicing, capping, polyadenylation) or cytoplasmic (transport, localization, translation, degr...
(PB) are two major distinguishable RNA granules in somatic cells and contain various ribosomal subunits, translation factors, scaffold proteins, RNA-binding proteins, RNA decay enzymes and helicases to exclude mRNAs from the cellular active translational pool. Although SG formation is inducible due to...
In this Review, we discuss the progress and new concepts on RNA-binding proteins and RNA biology and appraise them in the context of common cardiovascular clinical conditions, from cell and organ-wide perspectives. We also discuss how a better understanding of cardiac RNA-binding proteins can ...