RNA-binding proteins (RBPs) are critical effectors of gene expression, and as such their malfunction underlies the origin of many diseases. RBPs can recognize hundreds of transcripts and form extensive regulatory networks that help to maintain cell homeostasis. System-wide unbiased identification of ...
In this Review, we discuss the progress and new concepts on RNA-binding proteins and RNA biology and appraise them in the context of common cardiovascular clinical conditions, from cell and organ-wide perspectives. We also discuss how a better understanding of cardiac RNA-binding proteins can ...
Finding binding preferences of RNA binding proteins : Literature ReviewKazan, Hilal
Review article Genomic era analyses of RNA secondary structure and RNA-binding proteins reveal their significance to post-transcriptional regulation in plants 3RNA-binding proteins RNA-binding proteinsare a ubiquitous and heterogeneous class of proteins found in all organisms and characterized by the prese...
Review article RNA–protein interactions in vivo: global gets specific RNA-binding proteins (RBPs) impact every process in the cell; they act as splicing and polyadenylation factors, transport and localization factors, stabilizers and destabilizers, modifiers, and chaperones. RNA-binding capacity can ...
In the nucleus, some RNA-binding proteins (RBP) often function as AS regulators in a particular way in the disease course [13, 14]. Functional disruptions in RBPs may be a major cause or consequence of a disease [15, 16]. CUGBP Elav-like family (CELF) and muscleblind-like (MBNL) ...
很大程度上,潜在的分子机制是由RNA转录本与大量RNA结合蛋白(RNA binding proteins, RBPs)在物理层面的互作介导的,这些蛋白调节RNA剪接(splicing)、稳定性(stability)、核转运(nuclear export)和翻译(translation)等特性。因此,阐释这些RBPs的RNA结合...
RNA-binding proteins (RBPs) modulate all aspects of RNA metabolism, but a comprehensive picture of RBP expression across tissues is lacking. Here, we describe our development of the method we call HARD-AP that robustly retrieves RBPs and tightly associat
Regulation of pluripotency by RNA binding proteins. |核心内容: 建立、维持和退出多能性需要细胞分子机制的精确协调。 在破译这一复杂系统的许多方面,特别是在表观遗传学、转录和非编码RNA方面,已经取得了实质性的进展。 对转录后调控过程的关注较少,如选择性剪接、RNA加工和修饰、核输出、转录本稳定性的调节和翻...
RNA-binding proteins (RBPs) are central to most if not all cellular processes, dictating the fate of virtually all RNA molecules in the cell. Starting with pioneering work on ribosomal proteins, studies of bacterial RBPs have paved the way for molecular studies of RNA–protein interactions. Wor...