The multifaceted role of Fragile X-Related Protein 1 (FXR1) in cellular processes: an updated review on cancer and clinical applications Article Open access 18 January 2024 An in vivo genome-wide CRISPR screen identifies the RNA-binding protein Staufen2 as a key regulator of myeloid leukemia ...
RNA-binding proteins (RBPs) are central to most if not all cellular processes, dictating the fate of virtually all RNA molecules in the cell. Starting with pioneering work on ribosomal proteins, studies of bacterial RBPs have paved the way for molecular studies of RNA–protein interactions. Wor...
Two of the most widespread plant RNA-binding domains are the RNA Recognition Motif and the K Homology domain (see Table 1). The RNA Recognition Motif-containing protein family in particular is highly diversified within plants when compared to animals, with ∼50% of these proteins having no ...
our study found wtp53 protein was no significantly altered in RNPC1a over-expressed or silent MCF-7 cells (Figure5A). Level of p21 protein was increased in RNPC1a over-expressed MCF-7 and MDA-MB-231 cells (Figure5A and B). Mutp53 protein was decreased in RNPC...
RBP蛋白就是RNA Binding protein,LncRNA和蛋白片段相互结合,好不好做机制研究呢?小概率事件还是广泛存在于每个蛋白或者每个lncRNA上,这是一个值得去探索的问题,事实上蛋白和lncRNA互作要比咱们想象得广泛许多。比较经典的发现RBP蛋白的技术有iCLIP,PAR-CLIP 以及eCLIP。
Approaches to footprint RNA-protein binding sites 理解RBP生物学功能和分子机制的关键是鉴定所有RNA转录本的集合。此外,RBP的RNA结合位点或“足迹”(footprint)也可以帮助我们进一步了解其生物学活性。因此早期的研究主要依靠体外选择,利用RBP对固定...
Interestingly, in another research, TRIM25 mRNA serves as endogenous RNAs, binding with retinoic acid-inducible gene I (RIG-I) in innate immunity [160]. Whether TRIM family genes acting as the RNA binding protein or as the bound substrate, it helps to provide critical insights into diagnostic...
所以在RNA早期研究中,科研人员另辟蹊径,开发出一系列基于荧光蛋白的RNA示踪工具,即RNA结合蛋白—荧光蛋白系统(RNA binding protein-fluorescent protein, RBP-FP)。其中,基于噬菌体得到的MCP-FP系统最早被开发出来且应用最为广泛。该系统来源于噬菌体,MS2蛋白是一种噬菌体衣...
as well as age-associated neurodegeneration. Protein abnormalities and inclusion bodies are found to beaccompanied with the aged brain. Defects in the regulation of RNA metabolism were also seen in neurodegenerative disorders by involving the mutation ormis-localization of RNA binding proteins leading to...
In this Review, we discuss the progress and new concepts on RNA-binding proteins and RNA biology and appraise them in the context of common cardiovascular clinical conditions, from cell and organ-wide perspectives. We also discuss how a better understanding of cardiac RNA-binding proteins can ...