RNA pull-down实验:使用体外合成的双链RNA(包含错配)作为诱饵,捕获与之结合的蛋白质,然后通过质谱...
RNA Binding Protein (RBP) Expression and Disease Dynamics database (READ DB) is a non-redundant, curated database of human RBPs. RBPs curated from different experimental studies are reported with their annotation, tissue-wide RNA and protein expression levels, evolutionary conservation, disease asso...
An in vivo genome-wide CRISPR screen identifies the RNA-binding protein Staufen2 as a key regulator of myeloid leukemia Article 20 April 2020 Genomic basis for RNA alterations in cancer Article Open access 05 February 2020 Data availability The data that support the findings of this study ...
RNA 结合蛋白(RBP,RNA binding protein)能与RNA分子相互作用,影响RNA分子稳定性,剪接,细胞核输出以及靶标转录序列的翻译。因此找到RBP-RNA是如何相互作用,对于了解基因表达,细胞功能等具有重要意义。 跟预测miRNA靶基因一样,ENCORI不提一次性下载。那么如果你有好几个RBP需要研究,那么你就不得不在这个网站上查询好几...
研究表明,拟南芥ASCO-lncRNA竞争 NUCLEAR SPECKLE RNA- binding proteins (NSRs)并且隔绝NSRs以调节靶基因的选择性剪接模式(图4d)(Bardou et al. 2014)。lncRNA也是端粒酶分子机制的组成部分。例如,lncRNAAtTR是端粒酶的RNA亚基,它与端粒酶逆转录酶(TELOMERASE REVERSE TRANSCRIPTASE,TERT)相互作用,维持端粒的完整性和...
Similarly to how post-translational modifications can alter protein function, the direct and specific binding of RNA can also regulate protein function — a process called riboregulation. Variants in RBPs are increasingly being recognized as a cause of common cardiovascular diseases, and these RBPs ...
预测工具,用于预测RNA-蛋白互作关系。使用者输入Protein/RNA序列,在“Example”中选择预测类型:只预测RNA上Protein的靶位点/预测RNA(Protein)在Protein(RNA)上的靶位点,结果展示中序列下方为“+”处为可能存在的靶位点。 4、DeepBind:a tool for predicting the sequence specificities of DNA- and RNA-binding prote...
A comprehensive analysis of bound RNA targets is necessary to understand the role of anRNA-binding proteinin post-transcriptional gene regulation. This information is needed to determine the specificbinding sitesand sequence preferences (interaction motif(s)) of each RNA-binding protein. Initially, in...
别 名 Probable RNA-binding protein 20; Rbm20; RBM20_HUMAN; RNA-binding motif protein 20. 产品属性: 浓 度 1mg/1ml 规 格 0.2ml/200μg 抗体来源 Rabbit 克隆类型 polyclonal 交叉反应 Human, Mouse, Rat, Dog, Cow, Horse, Sheep 产品类型 一抗 研究领域 心 转录调节因子 蛋白分子量 predicted ...
RNA结合蛋白(RNA-binding protein, RBP)通常被认为是通过一个或多个RNA结合结构域(RBD)来结合RNA并改变结合RNA命运或功能的蛋白质。这些RBP广泛控制RNA生命周期的每个阶段,包括mRNA的合成和成熟,非编码RNA(non-coding RNA, ncRNA)的激活、剪切、降解等,因此RNA-蛋白质相互作用越来越被认为是转录组和蛋白质组调节的...