RNA-binding proteins (RBPs) can regulate gene expression through directly binding to messenger RNAs (mRNAs), as well as by blocking microRNA biogenesis at the post-transcription level [1]. RBPs reportedly function in various cellular processes, particularly in the multiple steps of RNA processing...
protein function prediction using DNA binding and RNA binding proteins as a test caseOf the currently identified protein sequences, 99.6% have never been observed in the laboratory as proteins and their molecular function has not been established experimentally. Predicting the function of such proteins...
[1] Lunde, B. M.; Moore, C.; Varani, G., RNA-binding proteins: modular design for efficient function. Nature reviews. Molecular cell biology 2007,8 (6), 479-90. [2] Wheeler, E. C.; Van Nostrand, E. L.; Yeo, G. W., Advances and challenges in the detection of transcriptome-...
Nucleic acid sequence evolution has an important role in the development of DRBP function. Emerging studies of rapidly evolving lncRNAs suggest that RNA binding by proteins that were previously thought of as DNA-specific may be a widespread phenomenon. ...
RNA结合蛋白(RNA-binding proteins,RBPs)在调节细胞环境中RNA的功能方面发挥着重要作用,但是在时间和空间上控制RBP活性的能力是有限的。 华东理工大学杨弋和陈显军实验室之前已研发的光控DNA结合蛋白和光遗传转录调控系统,可利用光实现基因转录的可逆、可调和时空调控。
Interestingly, this specificity of plant RNA-binding proteins and their roles in various stress responses suggest they might function primarily in plant exclusive processes [51]. Other RNA-binding domains include the cold-shock domain, dsRNA-binding domains, several types of zinc finger domains (the...
Uncovering the targets of RNA binding proteins is crucial to elucidate their cellular function in health and diseases. Several experimental methods for identifying RBPin vivobinding-sites transcriptome-wide have been developed, 开始说哪些办法能识别RBP体内结合位点转录组了 ...
RNA结合蛋白(RNAbindingProteins,RBPs)是基因表达的关键效应分子,因此它们的功能障碍是许多疾病的根源。 RNA结合蛋白可以识别数百个转录本,并形成广泛的调控网络,帮助维持细胞内环境的稳定。(蛋白质的合成需要mRNA作为模板,还需要相关蛋白作为“生产机器/工厂”) ...
[39] Kim GW, Imam H,Siddiqui A. The RNA binding proteins YTHDC1 and FMRP regulate the nuclear export of N(6)-methyladenosine- modified hepatitis B virus transcripts and affect the viral life cycle[J]. J Virol, 2...
Regulation of pluripotency by RNA binding proteins. |核心内容: 建立、维持和退出多能性需要细胞分子机制的精确协调。 在破译这一复杂系统的许多方面,特别是在表观遗传学、转录和非编码RNA方面,已经取得了实质性的进展。 对转录后调控过程的关注较少,如选择性剪接、RNA加工...