RNA-binding proteinLin28degraderoligonucleotideDefects in the functions of RNA binding proteins (RBPs) are at the origin of many diseases, however targeting RBPs with conventional drugs has proven difficult. PROTACs are a new class of drugs that mediate selective degradation of a target protein ...
RNA-Binding Proteins RNA-Binding Proteins(RNA-Binding Proteins) CAS: 化学式: 中文名RNA-Binding Proteins 英文名RNA-Binding Proteins 英文别名RNA-Binding Proteins
RNA-binding proteins (RBPs) are central to most if not all cellular processes, dictating the fate of virtually all RNA molecules in the cell. Starting with pioneering work on ribosomal proteins, studies of bacterial RBPs have paved the way for molecular studies of RNA–protein interactions. Wor...
RNA-binding proteins (RBPs) are critical effectors of gene expression, and as such their malfunction underlies the origin of many diseases. RBPs can recognize hundreds of transcripts and form extensive regulatory networks that help to maintain cell homeostasis. System-wide unbiased identification of ...
An antibody suitable for co-immunoprecipitation (Co-IP) of proteins is not necessarily suitable for RNA immunoprecipitation (RIP). Regardless of host, an antibody suitable for RIP targets accessible epitopes on the RNA binding protein of interest, which are not masked by the interaction with target...
Enrich DNA and RNA binding proteins up to 20,000 fold DNA coupled to Dynabeads via the streptavidin-biotin association can be re-used at least ten times The high stability and binding capacity of the DNA on Dynabeads allows binding of the target p...
In the classical view, RNA-binding proteins (RBPs) are defined as proteins that bind RNAs through well-defined RNA-binding domains (RBDs) to regulate RNA metabolism and functions. From: Molecular Therapy - Nucleic Acids, 2023 About this pageSet alert Also in subject areas: Medicine and Dentis...
System-wide approaches have unveiled an unexpected breadth of the RNA-bound proteomes of cultured cells. Corresponding information regarding RNA-binding proteins (RBPs) of mammalian organs is still missing, largely due to technical challenges. Here, we d
In the nucleus, some RNA-binding proteins (RBP) often function as AS regulators in a particular way in the disease course [13, 14]. Functional disruptions in RBPs may be a major cause or consequence of a disease [15, 16]. CUGBP Elav-like family (CELF) and muscleblind-like (MBNL) ...
RNA-binding protein immunoprecipitation (RIP) is the RNA analog of the more well-known ChIP application (chromatin immunoprecipitation), which identifies DNA targets of DNA-binding proteins in an in-vivo cellular context. RIP can be used to identify specific RNA molecules (of many types) ...