RNA-binding proteins (RBPs) are critical effectors of gene expression, and as such their malfunction underlies the origin of many diseases. RBPs can recognize hundreds of transcripts and form extensive regulatory networks that help to maintain cell homeostasis. System-wide unbiased identification of ...
RNA-binding proteinDatabaseOryza sativaRice seedProlamineRNA-binding proteins play critical roles at multiple steps during gene expression, including mRNA ... Robert T. Morris and Kelly A. Doroshenk and Andrew J. Crofts and Nicholas Lewis and Thomas W. Okita and John J. Wyrick - 《Plant Scien...
The RNA-Binding Protein DataBase (RBPDB) is a collection of experimental observations of RNA-binding sites, both in vitro and in vivo, manually curated from primary literature. To build RBPDB, we performed a literature search for experimental binding data for all RNA-binding proteins (RBPs) wit...
The information of RNA Binding Protein you could get are : Differential Expression: Significantly differentially expressed RBPs were identified by comparing their expression levels in cancer tissues with those in adjacent normal tissues using the DESeq2 (ver. 3.7) with the default settings. The raw ...
RBP2GO: a comprehensive pan-species database on RNA-binding proteins, their interactions and functions. Nucleic Acids Res. 49, D425–D436 (2021). Article CAS PubMed Google Scholar Hiller, M. et al. The mRNA binding proteome of proliferating and differentiated muscle cells. Genomics Proteom...
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研究表明,拟南芥ASCO-lncRNA竞争 NUCLEAR SPECKLE RNA- binding proteins (NSRs)并且隔绝NSRs以调节靶基因的选择性剪接模式(图4d)(Bardou et al. 2014)。lncRNA也是端粒酶分子机制的组成部分。例如,lncRNAAtTR是端粒酶的RNA亚基,它与端粒酶逆转录酶(TELOMERASE REVERSE TRANSCRIPTASE,TERT)相互作用,维持端粒的完整性和...
这些蛋白质的种类和功能多样,涵盖了膜受体、跨膜蛋白、糖蛋白等。此前的研究主要通过两种方法探究细胞表面的蛋白质:一种是基于糖标记的periodate-based方法,另一种是基于表面蛋白标记的NHS-based方法。此外,RNA生物研究中利用质谱技术,检测与RNA结合的 RNA结合蛋白(RBP, RNA-binding proteins)。
环状RNA(circular RNA,circRNA)是一类具有稳定共价闭合环状结构的非编码RNA。该类RNA不仅在肿瘤的发生发展中起着重要作用,还是多种疾病诊断和治疗的新型生物标志物。滋养细胞功能障碍可导致胚胎着床失败、胎盘发育异常及母-胎界面血管重塑不足,进而造成...
These proteins modify the RNA structure locally or globally; they may affect RNA trafficking, mRNA biosynthesis, translation, splicing, polyadenylation, differentiation and diseases. They may be part of the combinatorial tagging of mRNA and may control the localization, translation, and decay of mRNA ...