Mechanistically, HIFAL recruits prolyl hydroxylase 3 (PHD3) to pyruvate kinase 2 (PKM2) to induce its prolyl hydroxylation and introduces the PKM2/PHD3 complex into the nucleus via binding with heterogeneous nuclear ribonucleoprotein F (hnRNPF) to enhance HIF-1α transactivation. Reciprocally, HIF-...
Alternative splicing and related RNA binding proteins in human health and disease Yining Tao Qi Zhang Haoran Mu Signal Transduction and Targeted Therapy(2024) Matrin3 mediates differentiation through stabilizing chromatin loop-domain interactions and YY1 mediated enhancer-promoter interactions ...
YB-1 Y-box-binding protein m7G m7GPPPN RG4 RNA G-quadruplex PUS7 pseudouridine synthase 7 hnRNPF/H heterogeneous nuclear ribonucleoprotein F/H protein family RPM total reads per million SHOT-RNAs sex hormone-dependent tRNA-derived RNAs FZD3 Frizzled 3 HMBOX1 homeobox containing 1 BCAR3 breast...
Dengue Replication Ribosomal proteins NS1 Introduction The persisting epidemics of dengue disease in the world as well as the increasing number of cases, especially of the severe forms of the infection, along with the growing number of countries where dengue outbreaks are reported, make this disease...
The long isoform of CDK2 with 48 residues inserted owing to partial insertion of intron 5 has approximately half the specific activity compared to the normal form of CDK2 when forming a complex with cyclin A [40]. Poly(C)-binding proteins (PCBPs) bind to C-rich PPT in intron 4 and pr...
RNA-binding proteins (RBPs) have emerged as critical players in post-transcriptional gene regulation. Here we demonstrate that B cell-specific deletion of RBP hnRNP F leads to diminished production of class-switched antibodies with high affinities in response to a TD antigen challenge. B cells ...
Overexpression of the longevity gene Klotho prolongs lifespan, while its knockout shortens lifespan and impairs cognition via perturbation of myelination and synapse formation. However, comprehensive analysis of Klotho knockout effects on mammalian brain
Li et al. revealed that hnRNPF showed a significant increase in BC tissues [24]. Importantly, Wang et al. showed that hnRNPF interacts with lncRNA-UCA1 to coregulate the malignant phenotypes of esophageal squamous cell carcinoma [25]. However, the relationship between hnRNPF and LINC01189 expre...
The body resists metastasis by a variety of mechanisms through the actions of a class of proteins known as metastasis suppressors, of which about a dozen are known. It has also been determined that one of the critical events required is the growth of a new network of blood vessels, that is...
FIG. 5. KRAS and TAK1 regulate β-catenin nuclear localization and transcriptional activity in KRAS-dependent cancer cells. (A) TOP-FLASH luciferase reporter activity as a function of lentiviral shRNA-mediated KRAS depletion at increasing MOIs in LS174T/SW1463 (KRAS-independent) versus SW620/SK...