Studies have demonstrated that RNA-binding protein HuR modulates hypoxic signaling in several cancers, however, its function in the disc is unknown. HuR did not show cytoplasmic translocation in hypoxia and its silencing did not alter levels of Hif-1伪 or HIF-targets in NP cells. RNA-Sequencing...
RNA binding proteins are becoming recognized as potential mediators of cardiac physiology and pathology, but the role of HuR, an RNA binding protein highly expressed in myocytes, in acute cardiac I/R injury is unknown. HuR has been shown in other tissues to be a critical post-transcriptional ...
RNA-binding proteins (RBPs) play an essential role in governing the fate of mRNA transcripts from biogenesis, stabilization, translation to RNA decay5,6. Several RBPs have been reported as adipocyte regulators by affecting different aspects of RNA processing. SFRS10 and Sam 68 modulate the adipoc...
结果 在MC中,HG可引起NOX4蛋白的快速上调,NOX4 mRNA 3‘非翻译区(3’-UTR)含有大量富含AU的元件(Ares),它们是RNA结合蛋白HuR的潜在结合位点。结果发现HG促进HuR的活化/表达,并且HuR是HG诱导的NOX4蛋白表达/mRNA翻译、ROS生成以及随后的MC纤维...
Jin H, Chen Y, Ren J, Huang J, Zhao Y, Liu H. TERC suppresses PD-L1 expression by downregulating RNA binding protein HuR. Sci China Life Sci. 2022 Jun 1. 研究背景 细胞程序性死亡-配体1(PD-L1)又称B7同源体1(B7-H1),是细胞程序性...
Glutaminase (GLS) is directly related to cell growth and tumor progression, making it a target for cancer treatment. The RNA-binding protein HuR (encoded by the ELAVL1 gene) influences mRNA stability and alternative splicing. Overexpression of ELAVL1 is
RNA-binding proteinTumor suppressor protein p53 plays a crucial role in maintaining genomic integrity in response to DNA damage. Regulation of translation of p53 mRNA is a major mode of regulation of p53 expression under genotoxic stress. The AU/U-rich element-binding protein HuR has been shown ...
2019年12月3日,中国科学院遗传与发育生物学研究所郭伟翔课题组在Cell Reports杂志上发表文章Developmental Cytoplasmic-to-Nuclear Translocation of RNA-Binding Protein HuR Is Required for Adult Neurogenesis,揭示了HuR的易位表达是两个阶段神经发生差异的重要调控分子机制之一。
mRNA 稳定性和翻译的变化主要是通过特定mRNA 序列(顺式元件)与两种主要的反式作用因子——RNA 结合蛋白(RNA-binding protein,RBP)和微小RNA(microRNA,miRNA)相互作用而启动的过程来控制的[1]。RBP 参与RNA 代谢的各个环节,包括RNA 剪接、多聚腺苷酸序列编辑、RNA 转移、维持RNA 的稳定和降解、细胞内定位和翻译...
therresearchinHuRprotein'Sexpressionincytoplasm. 【Keywords】HuRprotein;Coloncarcinoma;Ovariancancer;Breastcancer;Immunofluorescence (ThePracticalJournalofCancer,2007,22:005～008) HuR是RNA结合蛋白中胚胎致死异常视觉(em— bryonielethalabnormalvision,ELAV)家族的一员,分 子量为36kD.在哺乳动物细胞中广泛表达….许...