Mol Immunol, 2000,37 : 1- 11.The Jak-STAT pathway[J] . Kazuroni Imada,Warren J Leonard.Molecular Immunology . 2000 (1)Imada K & Leonard WJ (2000) The Jak-STAT pathway. Mol Immunol, 37, 1-11.Imada K, Leonard WJ. The Jak-STAT pathway. Mol Immunol. 2000;37:1-11....
The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway was discovered more than a quarter-century ago. As a fulcrum of many vital cellular processes, the JAK/STAT pathway constitutes a rapid membrane-to-nucleus signaling module and induces the expression of ...
SHORT COMMUNICATIONActivation of the JAK/STAT pathway in Behcet’s diseaseThis article has been corrected since Advance Online Publication and an erratum is also printed in this issue.A Tulunay 1 , MG Dozmorov 2,3 , F Ture-Ozdemir 1 , V Yilmaz 4 , E Eksioglu-Demiralp 1 , F Alibaz-...
The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeostasis in animals, from humans to ies. In mammals, the JAK/STAT pathway is the principal signaling ...
We look back on the discoveries that the tyrosine kinases TYK2 and JAK1 and the transcription factors STAT1, STAT2, and IRF9 are required for the cellular response to type I interferons. This initial description of the JAK-STAT pathway led quickly to additional discoveries that type II ...
Xuan YT, Guo Y, Han H, Zhu Y, Bolli R (2001) An essential role of the JAK-STAT pathway in ischemic preconditioning. Proc Natl Acad Sci U S A 98(16):9050–9055. doi: 10.1073/pnas.161283798Xuan Y-T, Guo Y, Han H, Zhu Y, Bolli R. An essential role of the JAK-STAT pathway...
The Janus kinase (JAK) signal transducer and activator of transcription (JAK-STAT) pathway is an evolutionarily conserved mechanism of transmembrane signal transduction that enables cells to communicate with the exterior environment. Various cytokines, interferons, growth factors, and other specific molecule...
STAT5 contributes to mast cell homeostasis, by mediating proliferation, survival, and mediator release. Regulators of the JAK-STAT pathway, such as the suppressors of cytokine signaling (SOCS) and protein inhibitor of activated STAT (PIAS) proteins, are required to fine tune the immune response ...
Universal and essential to cytokine receptor signaling, the JAK-STAT pathway is one of the best understood signal transduction cascades. Almost 40 cytokine receptors signal through combinations of four JAK and seven STAT family members, suggesting commonality across the JAK-STAT signaling system. Despite...
The JAK/STAT signaling pathway plays a pivotal role in wound healing, and it regulates major cellular process such as cell proliferation, cell migration, differentiation and apoptosis [40]. Jere et al. [41] recently reported a significant increase in migration and proliferation of normal wounded,...