We look back on the discoveries that the tyrosine kinases TYK2 and JAK1 and the transcription factors STAT1, STAT2, and IRF9 are required for the cellular response to type I interferons. This initial description of the JAK-STAT pathway led quickly to additional discoveries that type II ...
Stark, G. R. & Darnell, J. E. Jr. The JAK-STAT pathway at twenty.Immunity36, 503–514 (2012).This review, co-authored by the scientists most credited with unravelling the signal transduction pathways mediating cellular responses to type I interferons, provides a personal and captivating hist...
E. Jr. The JAK-STAT pathway at twenty. Immunity 36, 503–514 (2012). This is a comprehensive overview including a historical perspective on the modulation of JAK–STAT signalling and its implications on cytokine biology. CAS PubMed PubMed Central Google Scholar Yoshimura, A., Naka, T. &...
The interleukin-6 (IL-6)/Janus kinase (JAK)/signal transducer and activator of transcription 3 (STAT3) pathway is aberrantly hyperactivated in many types of cancer, and such hyperactivation is generally associated with a poor clinical prognosis. In this
it facilitates various cellular reactions to stress such as hypoxia, endotoxin, ultraviolet light, and hyperosmolarity [14]. Hence, the pharmacologic intervention on JAK/STAT pathway is promising for the mediation of several diseases and JAK inhibitors are currently being investigated for many indication...
STAT4 is an important molecule in the IL-12 signaling pathway, and STAT5a and STAT5b are stimulated by IL-2 and erythropoietin. STAT6 is important for IL-4 and IL-13 signaling. After a cytokine binds to its receptor, Janus-activated kinase (JAK) is phosphorylated (Imada and Leonard, ...
Chimeric antigen receptor (CAR) T cell (CAR-T cell) therapy based on gene editing technology represents a significant breakthrough in personalized immunotherapy for human cancer. This strategy uses genetic modification to enable T cells to target tumor-s
PKCzeta at the crossroad of NF-kap- paB and Jak1/Stat6 signaling pathways. Cell Death Differ. 2006;13:702–11. 7. Yang JQ, Leitges M, Duran A, Diaz-Meco MT, Moscat J. Loss of PKC lambda/iota impairs Th2 establishment and allergic airway inflammation in vivo. Proc Natl Acad Sci...
(JAK/STAT) pathway [103,104,106]. Tumor necrosis factor alpha (TNFα) also activatesPMLtranscription by promoting STAT1-dependent transactivation of thePMLpromoter [107,108]. Moreover, interleukin 6 (IL-6) enhancesPMLtranscription via NF-κB and JAK-STAT pathways [109]. In summary,PML...
breakneck growth in the quarter century since its discovery and has yielded a stream of basic and clinical insights that have profoundly influenced modern understanding of human health and disease, exemplified by the bench-to-bedside success of Jak inhibitors ('jakinibs') and pathway-targeting drugs...