We look back on the discoveries that the tyrosine kinases TYK2 and JAK1 and the transcription factors STAT1, STAT2, and IRF9 are required for the cellular response to type I interferons. This initial description of the JAK-STAT pathway led quickly to additional discoveries that type II ...
We look back on the discoveries that the tyrosine kinases TYK2 and JAK1 and the transcription factors STAT1, STAT2, and IRF9 are required for the cellular response to type I interferons. This initial description of the JAK-STAT pathway led quickly to additional discoveries that type II interfer...
E. Jr. The JAK-STAT pathway at twenty. Immunity 36, 503–514 (2012). This is a comprehensive overview including a historical perspective on the modulation of JAK–STAT signalling and its implications on cytokine biology. CAS PubMed PubMed Central Google Scholar Yoshimura, A., Naka, T. &...
Stark, G. R. & Darnell, J. E. Jr. The JAK-STAT pathway at twenty.Immunity36, 503–514 (2012).This review, co-authored by the scientists most credited with unravelling the signal transduction pathways mediating cellular responses to type I interferons, provides a personal and captivating hist...
breakneck growth in the quarter century since its discovery and has yielded a stream of basic and clinical insights that have profoundly influenced modern understanding of human health and disease, exemplified by the bench-to-bedside success of Jak inhibitors ('jakinibs') and pathway-targeting drugs...
The JAK-STAT pathway at twenty. We look back on the discoveries that the tyrosine kinases TYK2 and JAK1 and the transcription factors STAT1, STAT2, and IRF9 are required for the cellular ... G Stark,JD Jr - 《Immunity》 被引量: 1312发表: 2012年 Contribution of STAT SH2 groups to sp...
Hence, the pharmacologic intervention on JAK/STAT pathway is promising for the mediation of several diseases and JAK inhibitors are currently being investigated for many indications [15]. The main JAK-STAT enzymes comprise four of the JAK type (JAK1, JAK2, JAK3, and tyrosine kinase 2 [Tyk2]...
This study employed the use of immunoblotting to examine response of a potent cell cycle and apoptosis regulator, known as the Janus kinase-signal transducer and activator of transcription (JAK-STAT) signaling pathway, to freezing and thawing in the liver and skin of the wood frog. This ...
The interleukin-6 (IL-6)/Janus kinase (JAK)/signal transducer and activator of transcription 3 (STAT3) pathway is aberrantly hyperactivated in many types of cancer, and such hyperactivation is generally associated with a poor clinical prognosis. In this
E. Jr. The JAK–STAT pathway at twenty. Immunity 36, 503–514 (2012). Article CAS PubMed PubMed Central Google Scholar Wack, A., Terczyńska-Dyla, E. & Hartmann, R. Guarding the frontiers: the biology of type III interferons. Nat. Immunol. 16, 802–809 (2015). Article CAS Pub...