We look back on the discoveries that the tyrosine kinases TYK2 and JAK1 and the transcription factors STAT1, STAT2, and IRF9 are required for the cellular response to type I interferons. This initial description of the JAK-STAT pathway led quickly to additional discoveries that type II ...
Stark, G. R. & Darnell, J. E. Jr. The JAK-STAT pathway at twenty.Immunity36, 503–514 (2012).This review, co-authored by the scientists most credited with unravelling the signal transduction pathways mediating cellular responses to type I interferons, provides a personal and captivating hist...
The JAK-STAT pathway at twenty. We look back on the discoveries that the tyrosine kinases TYK2 and JAK1 and the transcription factors STAT1, STAT2, and IRF9 are required for the cellular ... G Stark,JD Jr - 《Immunity》 被引量: 1312发表: 2012年 Contribution of STAT SH2 groups to sp...
In this review, we aim to introduce the JAK-STAT pathway and its regulator proteins and elucidate the role of them in the differentiation of T helper(Th) cell subsets. Eventually, novel and approved therapeutic strategies are discussed in order to target the JAK-STAT pathway and its regulators...
breakneck growth in the quarter century since its discovery and has yielded a stream of basic and clinical insights that have profoundly influenced modern understanding of human health and disease, exemplified by the bench-to-bedside success of Jak inhibitors ('jakinibs') and pathway-targeting drugs...
E. Jr. The JAK-STAT pathway at twenty. Immunity 36, 503–514 (2012). This is a comprehensive overview including a historical perspective on the modulation of JAK–STAT signalling and its implications on cytokine biology. CAS PubMed PubMed Central Google Scholar Yoshimura, A., Naka, T. &...
Five cases also had mutations of JAK-STAT pathway-related genes at the same time. Though recurrent Chr9q gains were reported in mantle cell lymphoma(MCL), its frequency was lower, and the characteristic mutated genes in MCL were not related to the JAK-STAT pathway. These findings indicated ...
Hence, the pharmacologic intervention on JAK/STAT pathway is promising for the mediation of several diseases and JAK inhibitors are currently being investigated for many indications [15]. The main JAK-STAT enzymes comprise four of the JAK type (JAK1, JAK2, JAK3, and tyrosine kinase 2 [Tyk2]...
3C), we may conclude that PMA-activated Stat3 is involved in the major Jak/Stat pathway and is sufficient for activating the SOCS genes. These results seem to be related to the cell type specificity of astrocytes. Thus, we propose that Stat3 plays a major role in SOCS induction by PMA ...
The interleukin-6 (IL-6)/Janus kinase (JAK)/signal transducer and activator of transcription 3 (STAT3) pathway is aberrantly hyperactivated in many types of cancer, and such hyperactivation is generally associated with a poor clinical prognosis. In this