We look back on the discoveries that the tyrosine kinases TYK2 and JAK1 and the transcription factors STAT1, STAT2, and IRF9 are required for the cellular response to type I interferons. This initial description of the JAK-STAT pathway led quickly to additional discoveries that type II ...
E. Jr. The JAK-STAT pathway at twenty. Immunity 36, 503–514 (2012). This is a comprehensive overview including a historical perspective on the modulation of JAK–STAT signalling and its implications on cytokine biology. CAS PubMed PubMed Central Google Scholar Yoshimura, A., Naka, T. &...
breakneck growth in the quarter century since its discovery and has yielded a stream of basic and clinical insights that have profoundly influenced modern understanding of human health and disease, exemplified by the bench-to-bedside success of Jak inhibitors ('jakinibs') and pathway-targeting drugs...
The Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway plays critical roles in orchestrating of immune system, especially cytokine receptors and they can modulate the polarization of T helper cells. This pathway is regulated by an array of regulator proteins, including...
Thus, the JAK/STAT pathway has been shown to be involved in carcinogenesis under a background of inflammation. Furthermore, accumulating evidence indicates that the JAK/STAT pathway might be involved in multiple immune functions: STAT1 and STAT4 mainly induce IFNγ expression in Th1 cells, STAT6...
Research has demonstrated that SHP2 promotes the signaling cascade of the ERK pathway, while inhibiting stem cell self-renewal and differentiation in the JAK/STAT3 pathway [6]. In cytokine-dependent hematopoietic cell lineages, SHP2 has been proven to be involved in signal transduction pathways ...
PKCzeta at the crossroad of NF-kap- paB and Jak1/Stat6 signaling pathways. Cell Death Differ. 2006;13:702–11. 7. Yang JQ, Leitges M, Duran A, Diaz-Meco MT, Moscat J. Loss of PKC lambda/iota impairs Th2 establishment and allergic airway inflammation in vivo. Proc Natl Acad Sci...
Chimeric antigen receptor (CAR) T cell (CAR-T cell) therapy based on gene editing technology represents a significant breakthrough in personalized immunotherapy for human cancer. This strategy uses genetic modification to enable T cells to target tumor-s
The interleukin-6 (IL-6)/Janus kinase (JAK)/signal transducer and activator of transcription 3 (STAT3) pathway is aberrantly hyperactivated in many types of cancer, and such hyperactivation is generally associated with a poor clinical prognosis. In this
E. Jr. The JAK–STAT pathway at twenty. Immunity 36, 503–514 (2012). Article CAS PubMed PubMed Central Google Scholar Wack, A., Terczyńska-Dyla, E. & Hartmann, R. Guarding the frontiers: the biology of type III interferons. Nat. Immunol. 16, 802–809 (2015). Article CAS Pub...