Jmada K,Leonard WJ.The JAK/STAT pathway.Molecular Immunology. 2000Imada K, Leonard WJ. The JAK-STAT pathway. Mol Immunol 2000; 37:1-11.Imada, K., and W. J. Leonard. 2000. The Jak-STAT pathway. Mol. Immunol. 37:1-11.K. Imada and W. J. Leonard, "The Jak-STAT pathway," ...
Second, at the basic level, a secreted, (probably) protein product can profoundly alter within a few hours the fundamental properties of the treated cells. This very important original work was the beginning of JAK-STAT pathway studies. It was 30 years later through studying the induction of ...
The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway was discovered more than a quarter-century ago. As a fulcrum of many vital cellular processes, the JAK/STAT pathway constitutes a rapid membrane-to-nucleus signaling module and induces the expression of ...
anti-RAGE IgG and AG490 reduced the activation of microglia cells and obviously inhibited Aβ oligomer-induced release of TNF-α.Conclusions RAGE is the receptor of microglia in inflammatory response induced by the Aβ oligomer.The JAK /STAT pathway may participate in the release of TNF-α ...
Structure and function; Signalling pathway; Regulation of gene transcription; Binding activity; Activation and cellular responses.Weber-NordtR.M.Leukemia & LymphomaR.M. Weber-Nordt, R. Mertelsmann, J. Finke, The JAK-STAT pathway: signal transduction involved in proliferation, differenti- ation ...
Thus the JAK/STAT cascade provides a direct mechanism to translate an extracellular signal into a transcriptional response. In addition to the principal components of the pathway, other effector proteins have been identified that contribute to at least a subset of JAK/STAT signaling events. STAMs (...
There are a number of novel drugs currently in development, which target various pathway components; these include both biologics and small molecules at various stages of development. 展开 关键词: IL-4 JAK-STAT pathway STAT6 endotype phenotype therapy ‘Th2-high’ severe asthma ...
(2012). JAK/STAT pathway plays a critical role in the proinflammatory 55 56 57 gene expression and apoptosis of RAW264.7 cells induced by trichothecenes... J Tep,B Videmann,M Mazallon,... - 《Toxicology Letters》 被引量: 49发表: 2007年 Inflammatory cytokines regulate microRNA-155 expressio...
Evolving cognition of the JAK-STAT signaling pathway: autoimmune disorders and cancer Article Open access 19 May 2023 The JAK/STAT signaling pathway: from bench to clinic Article Open access 26 November 2021 JAK-STAT signaling maintains homeostasis in T cells and macrophages Article Open acce...
STAT5 contributes to mast cell homeostasis, by mediating proliferation, survival, and mediator release. Regulators of the JAK-STAT pathway, such as the suppressors of cytokine signaling (SOCS) and protein inhibitor of activated STAT (PIAS) proteins, are required to fine tune the immune response ...