The Jak-STAT pathway. Mol Immunol 37: 1-11, 2000.Imada K,Leonard W.The Jak-STAT pathway[J].Mol Immunol,2000;37(1-2):1-11.Imada K, Leonard WJ. The Jak-STAT pathway. Mol Immunol 2000; 37: 1-11Imada K, Leonard WJ. The Jak-STAT pathway. Mol Immunol 2000;37:1-11...
The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway serves as a paradigm for signal transduction from the extracellular environment to the nucleus. It plays a pivotal role in physiological functions, such as hematopoiesis
Second, at the basic level, a secreted, (probably) protein product can profoundly alter within a few hours the fundamental properties of the treated cells. This very important original work was the beginning of JAK-STAT pathway studies. It was 30 years later through studying the induction of ...
No longer ‘Just another kinase’, the Janus kinase (JAK) protein tyrosine kinases are now recognised as an integral component of the cytokine receptor subunits, and enzyme activation, as the initiat...
We look back on the discoveries that the tyrosine kinases TYK2 and JAK1 and the transcription factors STAT1, STAT2, and IRF9 are required for the cellular response to type I interferons. This initial description of the JAK-STAT pathway led quickly to additional discoveries that type II interfer...
The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway was discovered more than a quarter-century ago. As a fulcrum of many vital cellular processes, the JAK/STAT pathway constitutes a rapid membrane-to-nucleus signaling module and induces the expression of ...
JAK-STAT is an efficient and highly regulated system mainly dedicated to the regulation of gene expression. Primarily identified as functioning in hematopo... CS Nicolas,M Amici,ZA Bortolotto,... - JAK-STAT 被引量: 48发表: 2013年 Inhibitory Effect of Curcumol on Jak2-STAT Signal Pathway Mole...
Evolving cognition of the JAK-STAT signaling pathway: autoimmune disorders and cancer Article Open access 19 May 2023 The JAK/STAT signaling pathway: from bench to clinic Article Open access 26 November 2021 JAK-STAT signaling maintains homeostasis in T cells and macrophages Article Open acce...
The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway was discovered more than a quarter-century ago. As a fulcrum of many vital cellular processes, the JAK/STAT pathway constitutes a rapid membrane-to-nucleus signaling module and induces the expression of ...
22,23,24,25,26,27 Based on the ‘double-edged sword’ function of the JAK-STAT pathway in disease pathogenesis, numerous agents targeting the JAK-STAT pathway have been developed and tested in preclinical and clinical trials.28,29,30,31 As a result, first-generation JAK inhibitors, such ...