The Jak-STAT pathway. Mol Immunol 2000; 37:1-11.Imada K,Leonard WJ.The JA K-2 STAT pathway. Mol Immune . 2000Imada K, Leonard WJ. The Jak-STAT pathway. Mol Immunol. 2000;37:1-11.Imada K, Leonard WJ. The Jak-STAT pathway. Mol Immunol 2000;37:1-11...
Due to its critical role in human health and disease, therapeutic development targeting the JAK-STAT pathway has received considerable attention. Various strategies have been explored to modulate the pathway and restore its normal function.49,72One major approach involves the development of small molecu...
The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway serves as a paradigm for signal transduction from the extracellular environment to the nucleus. It plays a pivotal role in physiological functions, such as hematopoiesis, immune balance, tissue homeostasis, and surveill...
The JAK-STAT pathway is one of the central signaling pathways used by interferons and type I cytokines. Janus family tyrosine kinases (JAK kinases) are cytoplasmic tyrosine kinases that associate with cytokine receptor chains. These kinases are activated by cytokine binding, and then can phosphorylate...
Structure and function; Signalling pathway; Regulation of gene transcription; Binding activity; Activation and cellular responses.Weber-NordtR.M.Leukemia & LymphomaWeber-nordt R.M., Mertelsmann R. and Finke J. (1998) The JAK-STAT Pathway: Signal Transduction Involved in Proliferation, ...
these the JAK-STAT pathway is one of the architecturally simplest paradigms, allowing direct communication fromtransmembrane receptors to the nucleus (Figure 1). Pioneering work on the control of gene expression by interferons led to the discovery of this pathway; however, it is now recognized that...
kinase (JAK1) was observed to be upregulated in both CD14 + monocytes (1.95-fold) and CD4 + T lymphocytes (1.40-fold) of BD patients. Using canonical pathway enrichment analysis, JAK/STAT signaling was identif i ed as activated in both CD14 +monocytes (P=9.55E−03) and in CD4 +...
We look back on the discoveries that the tyrosine kinases TYK2 and JAK1 and the transcription factors STAT1, STAT2, and IRF9 are required for the cellular response to type I interferons. This initial description of the JAK-STAT pathway led quickly to additional discoveries that type II ...
The Janus kinase/signal transducer and activator of transcription (JAK-STAT) pathway mediates important responses in immune cells. Activation of any of the four JAK family members leads to phosphorylation of one or more of seven STAT family members. Phosphorylation of STAT family members leads to ...
Xuan, Y.T., Guo, Y., Han, H., Zhu, Y., Bolli, R., 2001. An essential role of the JAK-STAT pathway in ischemic preconditioning. Proc. Natl. Acad. Sci. USA 98, 9050-9055.Xuan YT, Guo Y, Han H, Zhu Y, Bolli R. An essential role of the JAK-STAT pathway in ischemic ...