The Jak-STAT pathway. Mol Immunol. 2000;37:1-11.Imada K, Leonard WJ (2000) The Jak-STAT pathway. Mol Immunol 37:1-11Imada K, Leonard WJ. The Jak-STAT pathway. Mol Immunol 2000;37:1-11.Kazuroni Imada,Warren J Leonard.The Jak-STAT pathway[J]. Molecular Immunology . 2000 (1)...
the C-termini of βc extracellular domains are approximately ~120 Å apart, a distance that appears too far to allow the formation of the JAK dimer necessary for signaling. Second, if the ~120 Å distance is deemed
The conservation of signaling cascades between humans and over more than 500 million years of evolutionary time, means that the genetic tractability of the fly can be used to its full advantage to understand the functional requirements for JAK-STAT pathway signaling across species. Here we review ...
1998. The JAK-STAT pathway: Signal transduction involved in proliferation, differentia- tion and transformation. Leuk Lymphoma 28:459-467.Weber-Nordt RM, Mertelsmann R, Finke J. The JAK-STAT pathway: Signal transduction involved in proliferation, differentiation and transformation. Leuk Lymphoma 1998...
The Janus kinase/signal transducer and activator of transcription (JAK-STAT) pathway mediates important responses in immune cells. Activation of any of the four JAK family members leads to phosphorylation of one or more of seven STAT family members. Phosphorylation of STAT family members leads to ...
We look back on the discoveries that the tyrosine kinases TYK2 and JAK1 and the transcription factors STAT1, STAT2, and IRF9 are required for the cellular response to type I interferons. This initial description of the JAK-STAT pathway led quickly to additional discoveries that type II ...
JAK isoforms and seven STAT isoforms known, JAK2 and STAT3 are highly expressed in the brain where they are present in the postsynaptic density (PSD).However, the cellular and molecular mechanisms by which the JAK/STAT pathway is involved in synaptic function is unknown.Using a variety of ...
Morgan Bldg., Lexington, KY 40506 , USA The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeostasis in animals, from humans to flies. In mammals, the...
An essential role of the JAK-STAT pathway in ischemic preconditioning. Proc Natl Acad Sci USA 98: 9050 -9055, 2001.Xuan YT,Guo Y,Han H,et al.An essential role of the JAK-STAT pathway in ischemic preconditioning.Proceedings of the National Academy of Sciences of the United States of ...
SHORT COMMUNICATIONActivation of the JAK/STAT pathway in Behcet’s diseaseThis article has been corrected since Advance Online Publication and an erratum is also printed in this issue.A Tulunay 1 , MG Dozmorov 2,3 , F Ture-Ozdemir 1 , V Yilmaz 4 , E Eksioglu-Demiralp 1 , F Alibaz-...