Jak/Stat signaling pathwayRecently, the impacts of microRNAs (miRNAs) have been identified in epilepsy (EP), this study was designed to assess the role of miR-183 in hippocampal neuron injury in EP. Rat EP models were established by injected with lithium-pilocarpine. The pathological observation...
The Janus kinase (JAK) signal transducer and activator of transcription (JAK-STAT) pathway is an evolutionarily conserved mechanism of transmembrane signal transduction that enables cells to communicate with the exterior environment. Various cytokines, i
Interleukin-1β Plays a Pivotal Role via the PI3K/Akt/mTOR Signaling Pathway in the Chronicity of Mesial Temporal Lobe Epilepsy Mesial temporal lobe epilepsy (MTLE) is the most common type of refractory epilepsy. It is often associated with hippocampal sclerosis, which is histopatho... Zhaohua...
The role of JAK-STAT signaling within the CNS. JAKSTAT. 2013;2:e22925. PubMed PubMed Central Google Scholar Murase S, McKay RD. Neuronal activity-dependent STAT3 localization to nucleus is dependent on Tyr-705 and Ser-727 phosphorylation in rat hippocampal neurons. Eur J Neurosci. 2014;39...
Malignant tumours of the digestive system cover a wide range of diseases that affect the health of people to a large extent. Angiogenesis is indispensable
JAK/STAT (Janus kinase/signal transducer and activator of transcription) signalling is an immune signalling pathway that regulates the processes of proliferation, differentiation, migration, cell survival, and antiviral immunity depending on the cell/tissue type and the physiological/pathophysiological state...
Tetramethylpyrazine attenuates blood-brain barrier disruption in ischemia/reperfusion injury through the JAK/STAT signaling pathway Eur. J. Pharmacol., 854 (2019), pp. 289-297 View PDFView articleView in ScopusGoogle Scholar [30] G. Zhang, T. Zhang, L. Wu, X. Zhou, J. Gu, C. Li, W...
SHP2 has been discovered to play a key role in the development of normal hematopoietic cells [7,8]. Research has demonstrated that SHP2 promotes the signaling cascade of the ERK pathway, while inhibiting stem cell self-renewal and differentiation in the JAK/STAT3 pathway [6]. In cytokine-...
In animal models of intestinal bowel diseases, the expression of pro-inflammatory cytokines (IL-1β and IL-6) was significantly reduced, while levels of IL-10 were increased. EXs also reduced JAK1 and STAT1 phosphorylation via the JAK-STAT signaling pathway. The suppression of IL-7, TNF-α...
show an interesting trend, in which the precise modulation of neurotrophin signaling could switch neurotrophins from being a “promoter” of pain to their beneficial neurotrophic role of supporting the nerves in their recovery, especially when a structural alteration is present, as in neuropathic pain...