of the JAK/STAT pathway is associated with various cancers and autoimmune diseases.In this review,we discuss the current knowledge about the composition,activation,and regulation of the JAK/STAT pathway.Moreover,we highlight the role of the JAK/STAT pathway and its inhibitors in various diseases....
[5] Huang IH, Chung WH, Wu PC, Chen CB. JAK-STAT signaling pathway in the pathogenesis of atopic dermatitis: An updated review.Front Immunol. 2022; 13: 1068260. [6] Hu X, Li J, Fu M, Zhao X, Wang W. The JAK/STAT signaling pathway: from bench to clinic.Signal Transduct Target...
The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway was discovered more than a quarter-century ago. As a fulcrum of many vital cellular processes, the JAK/STAT pathway constitutes a rapid membrane-to-nucleus signaling module and induces the expression of ...
[8] Huang IH, Chung WH, Wu PC, et al. JAK-STAT signaling pathway in the pathogenesis of atopic dermatitis: an updated review[J]. Front Immunol, 2022,13:1068260. doi: 10.3389/fimmu.2022.1068260. [9] Guttman-Ya...
1.6.2JAK/STAT Signaling Pathway Janus family of tyrosine kinases (JAK) and the signal transducer and activator of transcription (STAT) family is a major signaling pathway involved in cellular metabolism. The JAK/STAT signaling pathway is also involved in several cellular processes, such as prolifera...
The signalling strength, kinetics and specificity of the JAK–STAT pathway are modulated at many levels by distinct regulatory proteins. Here, we review recent studies on the regulation of the JAK–STAT pathway that will enhance our ability to design rational therapeutic strategies for immune ...
The Janus kinase/signal transduction and activator of transcription (JAK–STAT) signaling pathway is implicated in the pathogenesis of inflammatory an
1. Hu X, et al. The JAK/STAT signaling pathway: from bench to clinic. Signal Transduct Target Ther. 2021;6(1):402. Published 2021 Nov 26. 2. Salas A, et al. JAK-STAT pathway targeting for the treatment of inflammatory bowel disease. Nat Rev Gastroenterol Hepatol. 2020;17(6):323-...
JAK/STAT signaling pathway is involved in many diseases, including autoimmune diseases, which are characterized by a close interconnection between immune a
Here, we review the current understanding of the fundamental composition and function of the JAK-STAT signaling pathway. We also discuss advancements in the understanding of JAK-STAT–related pathogenic mechanisms; targeted JAK-STAT therapies for various diseases, especially immune disorders, and cancers...